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    Atrnl1 attractin like 1 [ Mus musculus (house mouse) ]

    Gene ID: 226255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atrnl1provided by MGI
    Official Full Name
    attractin like 1provided by MGI
    Primary source
    MGI:MGI:2147749
    See related
    Ensembl:ENSMUSG00000054843 AllianceGenome:MGI:2147749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Alp; Atrnl; Atrnlp
    Summary
    Predicted to enable Notch binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human ATRNL1 (attractin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 10.7), frontal lobe adult (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atrnl1 in Genome Data Viewer
    Location:
    19 D2; 19 53.31 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (57599248..58121775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (57610960..58133343)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6720468P15 gene Neighboring gene STARR-seq mESC enhancer starr_46555 Neighboring gene STARR-seq mESC enhancer starr_46556 Neighboring gene predicted gene, 32932 Neighboring gene STARR-positive B cell enhancer mm9_chr19:57717570-57717871 Neighboring gene STARR-positive B cell enhancer mm9_chr19:57729589-57729890 Neighboring gene STARR-seq mESC enhancer starr_46558 Neighboring gene STARR-seq mESC enhancer starr_46561 Neighboring gene STARR-seq mESC enhancer starr_46562 Neighboring gene STARR-seq mESC enhancer starr_46563 Neighboring gene STARR-seq mESC enhancer starr_46566 Neighboring gene STARR-seq mESC enhancer starr_46567 Neighboring gene predicted gene, 52385 Neighboring gene STARR-seq mESC enhancer starr_46569 Neighboring gene STARR-seq mESC enhancer starr_46571 Neighboring gene predicted gene, 32980 Neighboring gene microRNA 5623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:58218359-58218542 Neighboring gene predicted gene, 50287 Neighboring gene STARR-seq mESC enhancer starr_46573 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 1 Neighboring gene predicted gene, 46650 Neighboring gene predicted gene 10007

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of attractin homologs. Walker WP, et al. Genesis, 2007 Dec. PMID 18064672
    2. Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. Haqq AM, et al. Biochem J, 2003 Dec 15. PMID 14531729, Free PMC Article
    3. Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification. Stylianou IM, et al. Genetics, 2008 Mar. PMID 18245842, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Over-expression of ATRNL1 compensates for loss of ATRN.
      Title: Genetic analysis of attractin homologs.
    2. Identification of attractin-like protein as a binding partner of melanocortin-4 receptor (attractin-like protein).
      Title: Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    attractin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181415.4 → NP_852080.3  attractin-like protein 1 precursor

      See identical proteins and their annotated locations for NP_852080.3

      Status: VALIDATED

      Source sequence(s)
      AK147492, AY688677
      Consensus CDS
      CCDS29928.1
      UniProtKB/Swiss-Prot
      Q3UHB0, Q68HV2, Q6A051, Q80VI3, Q8BKS4, Q8K0P5
      Related
      ENSMUSP00000076514.6, ENSMUST00000077282.7
      Conserved Domains (8) summary
      cd03597
      Location:747 → 873
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      cd00041
      Location:92 → 207
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:1012 → 1057
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:520 → 573
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:888 → 937
      PSI; Plexin repeat
      pfam13418
      Location:467 → 513
      Kelch_4; Galactose oxidase, central domain
      pfam13854
      Location:351 → 391
      Kelch_5; Kelch motif
      cl19567
      Location:234 → 279
      DSL; Delta serrate ligand

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      57599248..58121775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250921.2 → XP_030106781.1  attractin-like protein 1 isoform X7

      Conserved Domains (4) summary
      cd03597
      Location:215 → 341
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      cd00055
      Location:480 → 525
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam01437
      Location:356 → 404
      PSI; Plexin repeat
      pfam13854
      Location:48 → 81
      Kelch_5; Kelch motif

    2. XM_011247244.2 → XP_011245546.1  attractin-like protein 1 isoform X3

      Conserved Domains (9) summary
      cd03597
      Location:704 → 830
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      PLN02153
      Location:410 → 556
      PLN02153; epithiospecifier protein
      PHA03098
      Location:272 → 410
      PHA03098; kelch-like protein; Provisional
      cd00041
      Location:92 → 162
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:969 → 1014
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:477 → 530
      Kelch; KELCH repeat [structural motif]
      pfam01414
      Location:178 → 236
      DSL; Delta serrate ligand
      pfam01437
      Location:845 → 893
      PSI; Plexin repeat
      pfam13854
      Location:308 → 348
      Kelch_5; Kelch motif

    3. XM_006527049.4 → XP_006527112.1  attractin-like protein 1 isoform X1

      Conserved Domains (9) summary
      cd03597
      Location:747 → 873
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      PLN02153
      Location:453 → 599
      PLN02153; epithiospecifier protein
      PHA03098
      Location:315 → 453
      PHA03098; kelch-like protein; Provisional
      cd00041
      Location:92 → 207
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:1012 → 1057
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:520 → 573
      Kelch; KELCH repeat [structural motif]
      pfam01414
      Location:221 → 279
      DSL; Delta serrate ligand
      pfam01437
      Location:888 → 936
      PSI; Plexin repeat
      pfam13854
      Location:351 → 391
      Kelch_5; Kelch motif

    4. XM_036161583.1 → XP_036017476.1  attractin-like protein 1 isoform X2

      Conserved Domains (9) summary
      cd03597
      Location:747 → 873
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      PLN02153
      Location:453 → 599
      PLN02153; epithiospecifier protein
      PHA03098
      Location:315 → 453
      PHA03098; kelch-like protein; Provisional
      cd00041
      Location:92 → 207
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:1012 → 1057
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:520 → 573
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:888 → 937
      PSI; Plexin repeat
      pfam13854
      Location:351 → 391
      Kelch_5; Kelch motif
      cl19567
      Location:234 → 279
      DSL; Delta serrate ligand

    5. XM_036161584.1 → XP_036017477.1  attractin-like protein 1 isoform X4

      Conserved Domains (9) summary
      cd03597
      Location:747 → 873
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      PLN02153
      Location:453 → 599
      PLN02153; epithiospecifier protein
      PHA03098
      Location:315 → 453
      PHA03098; kelch-like protein; Provisional
      cd00041
      Location:92 → 207
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:1012 → 1057
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:520 → 573
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:888 → 937
      PSI; Plexin repeat
      pfam13854
      Location:351 → 391
      Kelch_5; Kelch motif
      cl19567
      Location:234 → 279
      DSL; Delta serrate ligand

    6. XM_006527051.4 → XP_006527114.1  attractin-like protein 1 isoform X5

      Conserved Domains (9) summary
      cd03597
      Location:747 → 873
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      PLN02153
      Location:453 → 599
      PLN02153; epithiospecifier protein
      PLN02193
      Location:299 → 386
      PLN02193; nitrile-specifier protein
      cd00041
      Location:92 → 207
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:1012 → 1057
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:520 → 573
      Kelch; KELCH repeat [structural motif]
      pfam01414
      Location:221 → 279
      DSL; Delta serrate ligand
      pfam01437
      Location:888 → 936
      PSI; Plexin repeat
      pfam13854
      Location:351 → 391
      Kelch_5; Kelch motif

    7. XM_006527052.4 → XP_006527115.1  attractin-like protein 1 isoform X6

      Conserved Domains (9) summary
      cd03597
      Location:747 → 873
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      PLN02153
      Location:453 → 599
      PLN02153; epithiospecifier protein
      PHA03098
      Location:315 → 453
      PHA03098; kelch-like protein; Provisional
      cd00041
      Location:92 → 207
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:1012 → 1057
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:520 → 573
      Kelch; KELCH repeat [structural motif]
      pfam01414
      Location:221 → 279
      DSL; Delta serrate ligand
      pfam01437
      Location:888 → 936
      PSI; Plexin repeat
      pfam13854
      Location:351 → 391
      Kelch_5; Kelch motif

    RNA

    1. XR_001782587.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A051.2 GenPept UniProtKB/Swiss-Prot:Q6A051

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