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    Itih3 inter-alpha trypsin inhibitor, heavy chain 3 [ Mus musculus (house mouse) ]

    Gene ID: 16426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Itih3provided by MGI
    Official Full Name
    inter-alpha trypsin inhibitor, heavy chain 3provided by MGI
    Primary source
    MGI:MGI:96620
    See related
    Ensembl:ENSMUSG00000006522 AllianceGenome:MGI:96620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Intin3; Itih-3; ITI-HC3
    Summary
    This gene encodes one of the heavy subunits of inter alpha trypsin inhibitor that functions as a protease inhibitor circulating in the plasma. The encoded protein undergoes proteolytic processing to generate a mature glycoprotein that is linked to the other subunits via an ester bond between the C-terminal aspartic acid residue and the N-acetyl galactosamine residue of chondroitin sulfate. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in liver E18 (RPKM 638.5), liver adult (RPKM 152.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itih3 in Genome Data Viewer
    Location:
    14 B; 14 19.09 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30630529..30645748, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30908572..30923787, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter alpha-trypsin inhibitor, heavy chain 4 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene predicted gene, 41121

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury. Wu H, et al. Brain Res Bull, 2024 Jun 15. PMID 38641154
    2. The three heavy-chain precursors for the inter-alpha-inhibitor family in mouse: new members of the multicopper oxidase protein group with differential transcription in liver and brain. Chan P, et al. Biochem J, 1995 Mar 1. PMID 7534067, Free PMC Article
    3. Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. Diarra-Mehrpour M, et al. Biochim Biophys Acta, 1994 Oct 18. PMID 7522574
    4. Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14. Jean L, et al. Genomics, 1997 Apr 1. PMID 9126497
    5. The genes for the inter-alpha-inhibitor family share a homologous organization in human and mouse. Salier JP, et al. Mamm Genome, 1992. PMID 1371941

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury.
      Title: MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H3
    Names
    ITI heavy chain H3
    inter-alpha-inhibitor H3 chain
    inter-alpha-inhibitor heavy chain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424470.1 → NP_001411399.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform 2 preproprotein

      Status: REVIEWED

      Source sequence(s)
      CT025528

    2. NM_001424471.1 → NP_001411400.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform 3 preproprotein

      Status: REVIEWED

      Source sequence(s)
      CT025528

    3. NM_008407.3 → NP_032433.2  inter-alpha-trypsin inhibitor heavy chain H3 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_032433.2

      Status: REVIEWED

      Source sequence(s)
      CT025528
      Consensus CDS
      CCDS49434.1
      UniProtKB/Swiss-Prot
      E9QME9, Q61704, Q91WG9
      Related
      ENSMUSP00000006697.9, ENSMUST00000006697.17
      Conserved Domains (4) summary
      smart00609
      Location:29 → 158
      VIT; Vault protein Inter-alpha-Trypsin domain
      TIGR03788
      Location:47 → 602
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam06668
      Location:683 → 870
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      cl00057
      Location:281 → 462
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30630529..30645748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518585.3 → XP_006518648.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X1

      Conserved Domains (3) summary
      smart00609
      Location:29 → 158
      VIT; Vault protein Inter-alpha-Trypsin domain
      pfam06668
      Location:697 → 885
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      cl00057
      Location:281 → 462
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_036158480.1 → XP_036014373.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X5

      Conserved Domains (2) summary
      pfam06668
      Location:529 → 717
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      cl00057
      Location:113 → 294
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_006518588.1 → XP_006518651.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X4

      Conserved Domains (3) summary
      smart00609
      Location:15 → 142
      VIT; Vault protein Inter-alpha-Trypsin domain
      pfam06668
      Location:681 → 869
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      cl00057
      Location:265 → 446
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RNA

    1. XR_003950825.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61704.3 GenPept UniProtKB/Swiss-Prot:Q61704

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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