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    Disp3 dispatched RND transporter family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 242748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Disp3provided by MGI
    Official Full Name
    dispatched RND transporter family member 3provided by MGI
    Primary source
    MGI:MGI:2444403
    See related
    Ensembl:ENSMUSG00000041544 AllianceGenome:MGI:2444403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ptchd2; RNDEu-2; G630052C06Rik
    Summary
    Predicted to be involved in negative regulation of neuron differentiation; positive regulation of lipid metabolic process; and positive regulation of neural precursor cell proliferation. Predicted to be located in cytoplasmic vesicle membrane; endoplasmic reticulum membrane; and nuclear membrane. Predicted to be active in cytoplasm. Orthologous to human DISP3 (dispatched RND transporter family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 4.6), frontal lobe adult (RPKM 4.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Disp3 in Genome Data Viewer
    Location:
    4 E2; 4 78.73 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148320890..148372653, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148236433..148288196, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3553 Neighboring gene F-box protein 44 Neighboring gene STARR-seq mESC enhancer starr_12077 Neighboring gene F-box protein 2 Neighboring gene predicted gene, 32603 Neighboring gene STARR-positive B cell enhancer ABC_E103 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene predicted gene, 23303 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene angiopoietin-like 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Peart MJ, et al. Proc Natl Acad Sci U S A, 2005 Mar 8. PMID 15738394, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein dispatched homolog 3
    Names
    RND-type protein RNDEu-2
    patched domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083342.1 → NP_001076811.1  protein dispatched homolog 3

      Status: VALIDATED

      Source sequence(s)
      AL606919, AL645605
      Consensus CDS
      CCDS38966.1
      UniProtKB/Swiss-Prot
      A3KFU9, Q0EEE3, Q69ZL6, Q6GQX3, Q6NS63
      UniProtKB/TrEMBL
      E9QL24
      Related
      ENSMUSP00000038490.9, ENSMUST00000047720.9
      Conserved Domains (1) summary
      cl21543
      Location:440 → 570
      MMPL; MMPL family

    RNA

    1. NR_149755.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK160667, AK160846, BB840401, BC072569, BM949407

    2. NR_154985.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606919, BB840401, BC070441

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148320890..148372653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538859.5 → XP_006538922.1  protein dispatched homolog 3 isoform X3

      Conserved Domains (1) summary
      COG1033
      Location:467 → 637
      COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

    2. XM_011250254.4 → XP_011248556.1  protein dispatched homolog 3 isoform X1

      Conserved Domains (1) summary
      COG1033
      Location:371 → 568
      COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

    3. XM_036164132.1 → XP_036020025.1  protein dispatched homolog 3 isoform X2

      Conserved Domains (1) summary
      COG1033
      Location:371 → 568
      COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

    RNA

    1. XR_390748.5 RNA Sequence

    2. XR_004941903.1 RNA Sequence

    3. XR_004941902.1 RNA Sequence

    4. XR_004941901.1 RNA Sequence

    5. XR_004941900.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KFU9.1 GenPept UniProtKB/Swiss-Prot:A3KFU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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