Ednra endothelin receptor type A [ Mus musculus (house mouse) ]

Gene ID: 13617, updated on 27-Nov-2024

Summary

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Official Symbol: Ednraprovided by MGI
Official Full Name: endothelin receptor type Aprovided by MGI
Primary source: MGI:MGI:105923
See related: Ensembl:ENSMUSG00000031616 AllianceGenome:MGI:105923
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ETa; ET-AR; AEA001; Gpcr10; Mhdaaea1
Summary: Enables endothelin receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; neural crest cell development; and regulation of D-glucose transmembrane transport. Is active in cell periphery. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 16.9), limb E14.5 (RPKM 15.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

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See Ednra in Genome Data Viewer

Location:: 8 C1; 8 36.63 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (78389658..78451081, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (77663029..77724452, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding.
Title: Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding.
miR-1929-3p Overexpression Alleviates Murine Cytomegalovirus-Induced Hypertensive Myocardial Remodeling by Suppressing Ednra/NLRP3 Inflammasome Activation.
Title: miR-1929-3p Overexpression Alleviates Murine Cytomegalovirus-Induced Hypertensive Myocardial Remodeling by Suppressing Ednra/NLRP3 Inflammasome Activation.
MicroRNA19293p participates in murine cytomegalovirusinduced hypertensive vascular remodeling through Ednra/NLRP3 inflammasome activation.
Title: MicroRNA‑1929‑3p participates in murine cytomegalovirus‑induced hypertensive vascular remodeling through Ednra/NLRP3 inflammasome activation.
Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
Title: Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
Loss-of-function of Endothelin receptor type A results in Oro-Oto-Cardiac syndrome.
Title: Loss-of-function of Endothelin receptor type A results in Oro-Oto-Cardiac syndrome.
Endothelin receptor-A mediates degradation of the glomerular endothelial surface layer via pathologic crosstalk between activated podocytes and glomerular endothelial cells.
Title: Endothelin receptor-A mediates degradation of the glomerular endothelial surface layer via pathologic crosstalk between activated podocytes and glomerular endothelial cells.
TRPA1 acts as a molecular target for ET-1, and sensitization of TRPA1 through ETAR-PKA pathway contributes to ET-1-induced mechanical hyperalgesia.
Title: ET(A)R and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.
The same anatomical and physiological consequences occur in Ednra(+/-); Plxna4(+/-) double heterozygotes, genetically confirming functional interaction. Second-order axon guidance therefore multiplexes a smaller number of guidance cues in sequential fashion, allowing precise refinement of axon trajectories.
Title: Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin.
Our findings suggest that endothelin type A receptor is a potential target for the management of sickle cell disease-associated pain, although this expectation needs to be further verified in clinical settings.
Title: Endothelin type A receptors mediate pain in a mouse model of sickle cell disease.
our results suggest a role for Ednra in Hoxa9/Meis1-driven leukemogenesis.
Title: The endothelin receptor type A is a downstream target of Hoxa9 and Meis1 in acute myeloid leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (5) 1 citation
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ednra (e-PCR), detects polymorphism
- UniSTS:142965

NoName (e-PCR)
- UniSTS:235933

NoName (e-PCR)
- UniSTS:235935

PMC262340P1 (e-PCR)
- UniSTS:272294

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables endothelin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables endothelin receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in artery smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in atrial cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis involved in innervation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to human chorionic gonadotropin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to human chorionic gonadotropin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to luteinizing hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cranial skeletal system development	IDA Inferred from Direct Assay more info	PubMed
involved_in cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic heart tube development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endothelin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endothelin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelin receptor signaling pathway involved in heart process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info
involved_in establishment of endothelial barrier	IDA Inferred from Direct Assay more info	PubMed
involved_in face development	IDA Inferred from Direct Assay more info	PubMed
involved_in face development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular endothelium development	IDA Inferred from Direct Assay more info	PubMed
involved_in glomerular filtration	IDA Inferred from Direct Assay more info	PubMed
involved_in glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within head development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparin metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in histamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in left ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle process involved in oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesenchymal cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in middle ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in noradrenergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in norepinephrine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pharyngeal arch artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in podocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in podocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in podocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cation channel activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kidney development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to cell leading edge	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal albumin absorption	IDA Inferred from Direct Assay more info	PubMed
involved_in renal albumin absorption	IGI Inferred from Genetic Interaction more info	PubMed
involved_in renal albumin absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal sodium ion absorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acetylcholine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in specification of segmental identity, mandibular segment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, maxillary segment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
is_active_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endothelin-1 receptor

Names: ET-A; G-protein coupled receptor 10; endothelin A receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.