Hsp90b1 heat shock protein 90, beta (Grp94), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsp90b1provided by MGI
Official Full Name: heat shock protein 90, beta (Grp94), member 1provided by MGI
Primary source: MGI:MGI:98817
See related: Ensembl:ENSMUSG00000020048 AllianceGenome:MGI:98817
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TA-3; Tra1; gp96; ERp99; GRP94; Targ2; Tra-1; endoplasmin
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in ERAD pathway; insulin processing; and protein folding. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Located in endoplasmic reticulum and sperm plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including central nervous system; heart; metanephros; pancreas; and respiratory system. Used to study male infertility due to globozoospermia. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in placenta adult (RPKM 303.0), CNS E11.5 (RPKM 168.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 43.05 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (86526705..86541308, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (86690841..86705444, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRP94 is an IGF-1R chaperone and regulates beta cell death in diabetes.
Title: GRP94 is an IGF-1R chaperone and regulates beta cell death in diabetes.
Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes.
Title: Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes.
Visualization of conformational transition of GRP94 in solution.
Title: Visualization of conformational transition of GRP94 in solution.
HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
Title: HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
HSP90beta promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-kappaB signaling.
Title: HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling.
Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity.
Title: Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity.
HSP90beta chaperoning SMURF1-mediated LATS proteasomal degradation in the regulation of bone formation.
Title: HSP90β chaperoning SMURF1-mediated LATS proteasomal degradation in the regulation of bone formation.
Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors.
Title: Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors.
The endoplasmic reticulum chaperone BiP is a closure-accelerating cochaperone of Grp94.
Title: The endoplasmic reticulum chaperone BiP is a closure-accelerating cochaperone of Grp94.
The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with (99m)Tc-Tilmanocept SPECT.
Title: The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with (99m)Tc-Tilmanocept SPECT.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129351 (e-PCR)
- UniSTS:212658

J03297 (e-PCR)
- UniSTS:124852

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within actin rod assembly	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to ATP	ISO Inferred from Sequence Orthology more info	PubMed
involved_in insulin processing	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in retrograde protein transport, ER to cytosol	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
part_of endoplasmic reticulum chaperone complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sperm plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: endoplasmin

Names: 94 kDa glucose-regulated protein; endoplasmic reticulum resident protein 99; heat shock protein 90 kDa beta member 1; polymorphic tumor rejection antigen 1; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; tumor rejection antigen gp96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011631.1 → NP_035761.1 endoplasmin precursor

See identical proteins and their annotated locations for NP_035761.1

Status: PROVISIONAL

Source sequence(s)

J03297

Consensus CDS

CCDS36019.1

UniProtKB/Swiss-Prot

P08113, P11427

UniProtKB/TrEMBL

Q3UAD6, Q91V38

Related

ENSMUSP00000020238.8, ENSMUST00000020238.14

Conserved Domains (3) summary

smart00387
Location:96 → 254

HATPase_c; Histidine kinase-like ATPases

PRK05218
Location:74 → 746

PRK05218; heat shock protein 90; Provisional

pfam00183
Location:257 → 783

HSP90; Hsp90 protein