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    Vars2 valyl-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 68915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vars2provided by MGI
    Official Full Name
    valyl-tRNA synthetase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1916165
    See related
    Ensembl:ENSMUSG00000038838 AllianceGenome:MGI:1916165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vars2l; mKIAA1885; 1190004I24Rik
    Summary
    Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and tail. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 24.0), stomach adult (RPKM 15.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vars2 in Genome Data Viewer
    Location:
    17 B1; 17 18.7 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35966526..35978531, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35655634..35667639, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mucin like 3 Neighboring gene surfactant associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E7529 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35808865-35809171 Neighboring gene general transcription factor II H, polypeptide 4 Neighboring gene STARR-positive B cell enhancer ABC_E7530 Neighboring gene STARR-seq mESC enhancer starr_42470 Neighboring gene discoidin domain receptor family, member 1 Neighboring gene STARR-seq mESC enhancer starr_42472 Neighboring gene predicted gene, 23864

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
    2. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables valine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    valine--tRNA ligase, mitochondrial
    Names
    valRS
    valyl-tRNA synthetase 2, mitochondrial (putative)
    valyl-tRNA synthetase, mitochondrial
    NP_780346.3
    XP_011244891.1
    XP_030105896.1
    XP_036016669.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429114.1 → NP_001416043.1  valine--tRNA ligase, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CR974483

    2. NM_001429115.1 → NP_001416044.1  valine--tRNA ligase, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      CR974483

    3. NM_175137.5 → NP_780346.3  valine--tRNA ligase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_780346.3

      Status: VALIDATED

      Source sequence(s)
      CR974483
      Consensus CDS
      CCDS37602.1
      UniProtKB/Swiss-Prot
      E9QMJ4, Q3U2A8, Q69Z78, Q6PGG3, Q6ZQL7, Q8BIN9
      Related
      ENSMUSP00000047917.9, ENSMUST00000043674.15
      Conserved Domains (3) summary
      cd07962
      Location:735 → 869
      Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
      cd00817
      Location:137 → 735
      ValRS_core; catalytic core domain of valyl-tRNA synthetases
      PTZ00419
      Location:90 → 1018
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional

    RNA

    1. NR_190578.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974483

    2. NR_190579.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974483

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35966526..35978531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246589.3 → XP_011244891.1  valine--tRNA ligase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PTZ00419
      Location:1 → 878
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional

    2. XM_036160776.1 → XP_036016669.1  valine--tRNA ligase, mitochondrial isoform X2

      Related
      ENSMUST00000165787.8
      Conserved Domains (1) summary
      PTZ00419
      Location:34 → 799
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional

    3. XM_030250036.1 → XP_030105896.1  valine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PTZ00419
      Location:90 → 518
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional

    RNA

    1. XR_003952175.1 RNA Sequence

    2. XR_003952174.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2A8.2 GenPept UniProtKB/Swiss-Prot:Q3U2A8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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