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    Daam2 dishevelled associated activator of morphogenesis 2 [ Mus musculus (house mouse) ]

    Gene ID: 76441, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Daam2provided by MGI
    Official Full Name
    dishevelled associated activator of morphogenesis 2provided by MGI
    Primary source
    MGI:MGI:1923691
    See related
    Ensembl:ENSMUSG00000040260 AllianceGenome:MGI:1923691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310016D11Rik
    Summary
    Predicted to enable actin binding activity and small GTPase binding activity. Involved in dorsal spinal cord development; negative regulation of oligodendrocyte differentiation; and regulation of Wnt signaling pathway. Acts upstream of or within determination of left/right symmetry. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human DAAM2 (dishevelled associated activator of morphogenesis 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 13.0), testis adult (RPKM 12.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Daam2 in Genome Data Viewer
    Location:
    17 C; 17 25.5 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (49763050..49871517, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (49456022..49564459, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41594 Neighboring gene STARR-positive B cell enhancer ABC_E1944 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:49568292-49568475 Neighboring gene molybdenum cofactor synthesis 1 Neighboring gene predicted gene, 52301 Neighboring gene kinesin family member 6 Neighboring gene VISTA enhancer mm276 Neighboring gene STARR-seq mESC enhancer starr_42779 Neighboring gene STARR-seq mESC enhancer starr_42780 Neighboring gene STARR-seq mESC enhancer starr_42781 Neighboring gene STARR-seq mESC enhancer starr_42782 Neighboring gene predicted gene 16555 Neighboring gene STARR-seq mESC enhancer starr_42783 Neighboring gene STARR-seq mESC enhancer starr_42784 Neighboring gene STARR-seq mESC enhancer starr_42785 Neighboring gene predicted gene, 19465

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Daam2 phosphorylation by CK2α negatively regulates Wnt activity during white matter development and injury. Wang CY, et al. Proc Natl Acad Sci U S A, 2023 Aug 29. PMID 37607236, Free PMC Article
    2. Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Colozza G, et al. Sci Adv, 2023 Nov 24. PMID 38000028, Free PMC Article
    3. Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin. Cristobal CD, et al. J Neurosci, 2022 Mar 2. PMID 35101966, Free PMC Article
    4. Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function. Jo J, et al. EMBO Rep, 2021 Dec 6. PMID 34633730, Free PMC Article
    5. The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation. Ding X, et al. Genes Dev, 2020 Sep 1. PMID 32792353, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin.
      Title: Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin.
    2. we generated Daam-deficient mice by gene targeting and found that Daam1, but not Daam2, is necessary for fetal survival. Embryonic development of Daam1 mutants was delayed most likely due to functional defects in the labyrinthine layer of the placenta. Examination of Daam2 and Daam1/2 double mutants revealed that Daam1 and Daam2 are functionally redundant during placental development.
      Title: Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2.
    3. Daam1 knockout mice that were also homozygous for Daam2 had stronger noncompaction cardiomyopathy, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation.
      Title: DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
    4. a pharmacological strategy to inhibit Daam2-PIP5K function, application of which stimulates remyelination after white matter injury
      Title: Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.
    5. involved in pivotal steps in neuronal cell differentiation and movement
      Title: Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system.
    6. Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development.
      Title: Identification and comparative expression analyses of Daam genes in mouse and Xenopus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal spinal cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of oligodendrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of oligodendrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in podocyte cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in podocyte cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of non-canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disheveled-associated activator of morphogenesis 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008231.2 → NP_001008232.2  disheveled-associated activator of morphogenesis 2 isoform 1

      See identical proteins and their annotated locations for NP_001008232.2

      Status: VALIDATED

      Source sequence(s)
      AC165258, AK009382, AY426536, BC050043
      Consensus CDS
      CCDS37648.1
      UniProtKB/Swiss-Prot
      E9QNU9, Q6TAB7, Q80U19, Q810J5
      Related
      ENSMUSP00000052085.7, ENSMUST00000057610.8
      Conserved Domains (3) summary
      pfam02181
      Location:595 → 1016
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_001379371.1 → NP_001366300.1  disheveled-associated activator of morphogenesis 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124748, AC165258
      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595 → 996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. NM_001379372.1 → NP_001366301.1  disheveled-associated activator of morphogenesis 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124748, AC165258
      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595 → 968
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      49763050..49871517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525090.5 → XP_006525153.1  disheveled-associated activator of morphogenesis 2 isoform X2

      Conserved Domains (3) summary
      pfam02181
      Location:587 → 988
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. XM_006525083.5 → XP_006525146.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525146.1

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595 → 996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. XM_036160827.1 → XP_036016720.1  disheveled-associated activator of morphogenesis 2 isoform X4

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:587 → 960
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    4. XM_006525089.5 → XP_006525152.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525152.1

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595 → 996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    5. XM_036160826.1 → XP_036016719.1  disheveled-associated activator of morphogenesis 2 isoform X3

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595 → 968
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    6. XM_006525084.5 → XP_006525147.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525147.1

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595 → 996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    7. XM_006525085.5 → XP_006525148.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525148.1

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595 → 996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    8. XM_006525086.4 → XP_006525149.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525149.1

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595 → 996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain

    9. XM_036160828.1 → XP_036016721.1  disheveled-associated activator of morphogenesis 2 isoform X5

      Conserved Domains (3) summary
      pfam06367
      Location:231 → 435
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:43 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:595 → 651
      FH2; Formin Homology 2 Domain

    RNA

    1. XR_004939600.1 RNA Sequence

    2. XR_004939598.1 RNA Sequence

    3. XR_004939599.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80U19.4 GenPept UniProtKB/Swiss-Prot:Q80U19

    Gene LinkOut

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