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    Lmntd2 lamin tail domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 72000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lmntd2provided by MGI
    Official Full Name
    lamin tail domain containing 2provided by MGI
    Primary source
    MGI:MGI:1919250
    See related
    Ensembl:ENSMUSG00000025500 AllianceGenome:MGI:1919250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1600016N20Rik
    Summary
    Predicted to be a structural constituent of chromatin. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in lamin filament. Orthologous to human LMNTD2 (lamin tail domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 95.4), colon adult (RPKM 6.2) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmntd2 in Genome Data Viewer
    Location:
    7 F5; 7 86.5 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140789903..140795617, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141209990..141215517, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51459 Neighboring gene predicted gene, 22019 Neighboring gene STARR-positive B cell enhancer ABC_E9115 Neighboring gene STARR-positive B cell enhancer ABC_E11375 Neighboring gene Harvey rat sarcoma virus oncogene Neighboring gene leucine rich repeat containing 56 Neighboring gene STARR-positive B cell enhancer ABC_E1749 Neighboring gene STARR-positive B cell enhancer ABC_E2854 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 Neighboring gene microRNA 210 Neighboring gene STARR-positive B cell enhancer ABC_E11376 Neighboring gene predicted gene, 51460 Neighboring gene PHD and ring finger domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Zheng S, et al. Genome Res, 2013 Jun. PMID 23636947, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in lamin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lamin tail domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347565.1 → NP_001334494.1  lamin tail domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC108908
      Consensus CDS
      CCDS90350.1
      UniProtKB/TrEMBL
      B7ZMW1
      Related
      ENSMUSP00000130905.2, ENSMUST00000170841.9
      Conserved Domains (1) summary
      pfam00932
      Location:395 → 487
      LTD; Lamin Tail Domain

    2. NM_001382822.1 → NP_001369751.1  lamin tail domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108908
      UniProtKB/Swiss-Prot
      Q0VET5, Q9CW10
      Conserved Domains (1) summary
      pfam00932
      Location:385 → 477
      LTD; Lamin Tail Domain

    3. NM_028050.2 → NP_082326.1  lamin tail domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_082326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC119093
      Consensus CDS
      CCDS40181.1
      UniProtKB/Swiss-Prot
      Q0VET5, Q9CW10
      Related
      ENSMUSP00000026573.6, ENSMUST00000026573.7
      Conserved Domains (1) summary
      pfam00932
      Location:385 → 477
      LTD; Lamin Tail Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140789903..140795617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153452.1 → XP_036009345.1  lamin tail domain-containing protein 2 isoform X6

      Conserved Domains (1) summary
      pfam00932
      Location:60 → 152
      LTD; Lamin Tail Domain

    2. XM_030243006.1 → XP_030098866.1  lamin tail domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q0VET5, Q9CW10
      Conserved Domains (1) summary
      pfam00932
      Location:385 → 477
      LTD; Lamin Tail Domain

    3. XM_030243007.1 → XP_030098867.1  lamin tail domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam00932
      Location:279 → 371
      LTD; Lamin Tail Domain

    4. XM_030243004.1 → XP_030098864.1  lamin tail domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B7ZMW1
      Conserved Domains (1) summary
      pfam00932
      Location:395 → 487
      LTD; Lamin Tail Domain

    5. XM_006536257.5 → XP_006536320.1  lamin tail domain-containing protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006536320.1

      Conserved Domains (1) summary
      pfam00932
      Location:279 → 371
      LTD; Lamin Tail Domain

    6. XM_030243005.2 → XP_030098865.1  lamin tail domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q0VET5, Q9CW10
      Conserved Domains (1) summary
      pfam00932
      Location:385 → 477
      LTD; Lamin Tail Domain

    7. XM_011249859.4 → XP_011248161.1  lamin tail domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011248161.1

      UniProtKB/TrEMBL
      B7ZMW1
      Conserved Domains (1) summary
      pfam00932
      Location:395 → 487
      LTD; Lamin Tail Domain

    8. XM_036153451.1 → XP_036009344.1  lamin tail domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam00932
      Location:279 → 371
      LTD; Lamin Tail Domain

    9. XM_036153450.1 → XP_036009343.1  lamin tail domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B7ZMW1
      Conserved Domains (1) summary
      pfam00932
      Location:395 → 487
      LTD; Lamin Tail Domain

    10. XM_017312319.1 → XP_017167808.1  lamin tail domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B7ZMW1
      Conserved Domains (1) summary
      pfam00932
      Location:395 → 487
      LTD; Lamin Tail Domain

    11. XM_006536258.5 → XP_006536321.1  lamin tail domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      pfam00932
      Location:395 → 482
      LTD; Lamin Tail Domain

    12. XM_006536259.5 → XP_006536322.1  lamin tail domain-containing protein 2 isoform X5

    RNA

    1. XR_880984.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VET5.1 GenPept UniProtKB/Swiss-Prot:Q0VET5

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