Boll boule homolog, RNA binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bollprovided by MGI
Official Full Name: boule homolog, RNA binding proteinprovided by MGI
Primary source: MGI:MGI:1922638
See related: Ensembl:ENSMUSG00000025977 AllianceGenome:MGI:1922638
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930554P13Rik; 4930597B14Rik
Summary: Predicted to enable identical protein binding activity; mRNA 3'-UTR binding activity; and translation activator activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and positive regulation of translational initiation. Predicted to act upstream of or within meiotic cell cycle. Predicted to be active in cytoplasm. Is expressed in central nervous system; germ cell of gonad; and sensory organ. Orthologous to human BOLL (boule homolog, RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 18.9) See more
Orthologs: human all
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Genomic context

Location:: 1 C1.2; 1 28.08 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (55282725..55402948, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (55243566..55363789, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

asked whether BOULE, the founding member of DAZ family proteins, is a component of the SGs. We show that BOULE is recruited to the SGs upon heat stress, and that these SGs are developmental stage-specific
Title: BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress Granules in the Mouse Male Germ Cells.
These results showed that IGF1 regulated the expression of BOULE and CDC25A mRNAs via ERK1/2 signaling and in T-independent pathway during spermatogenesis in the adult mouse testes.
Title: IGF1 regulation of BOULE and CDC25A transcripts via a testosterone-independent pathway in spermatogenesis of adult mice.
demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl
Title: A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.
Expression of key regulators of spermiogenesis was unaffected in Boule(-/-) mice, suggesting that Boule regulates germ-cell differentiation through a novel pathway.
Title: A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

Boll (e-PCR), detects polymorphism
- UniSTS:478989

PMC34683P1 (e-PCR)
- UniSTS:273229

NoName (e-PCR)
- UniSTS:490575

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation activator activity	IEA Inferred from Electronic Annotation more info
enables translation activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein boule-like

Names: bol, boule-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113367.3 → NP_001106838.1 protein boule-like isoform 2

Status: VALIDATED

Source sequence(s)

AC122223

Consensus CDS

CCDS48261.1

UniProtKB/TrEMBL

E9PWH1, F7CFY0

Related

ENSMUSP00000110066.4, ENSMUST00000114423.7
NM_001367887.2 → NP_001354816.1 protein boule-like isoform 3

Status: VALIDATED

Source sequence(s)

AC122223

UniProtKB/TrEMBL

G3UYE8

Related

ENSMUSP00000134054.2, ENSMUST00000173983.8
NM_001368767.2 → NP_001355696.1 protein boule-like isoform 4

Status: VALIDATED

Source sequence(s)

AC122223

UniProtKB/TrEMBL

G3UYE8

Conserved Domains (2) summary

TIGR01628
Location:45 → 293

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12673
Location:43 → 123

RRM_BOULE; RNA recognition motif in protein BOULE
NM_001368768.1 → NP_001355697.1 protein boule-like isoform 2

Status: VALIDATED

Source sequence(s)

AC122223

Consensus CDS

CCDS48261.1

UniProtKB/TrEMBL

E9PWH1, F7CFY0
NM_029267.5 → NP_083543.2 protein boule-like isoform 1

Status: VALIDATED

Source sequence(s)

AC122223

Consensus CDS

CCDS48262.1

UniProtKB/Swiss-Prot

E9QPQ9, Q924M5, Q9D4V2

UniProtKB/TrEMBL

G3UYE8

Related

ENSMUSP00000084868.4, ENSMUST00000087585.10

Conserved Domains (2) summary

TIGR01628
Location:45 → 283

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12673
Location:43 → 123

RRM_BOULE; RNA recognition motif (RRM) found in protein BOULE