Igf2os insulin-like growth factor 2, opposite strand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igf2osprovided by MGI
Official Full Name: insulin-like growth factor 2, opposite strandprovided by MGI
Primary source: MGI:MGI:1195257
See related: Ensembl:ENSMUSG00000086266 AllianceGenome:MGI:1195257
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Peg8; Igf2as
Summary: This is an imprinted and paternally expressed gene transcribed in antisense to Igf2 (insulin-like growth factor 2). This gene is currently represented as producing a non-coding RNA; however, transcripts were observed to localize in the cytoplasm to polysomes, suggesting that translation may occur. [provided by RefSeq, Sep 2016]
Expression: Biased expression in limb E14.5 (RPKM 10.0), placenta adult (RPKM 8.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 87.99 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (142213417..142224093)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (142659680..142670356)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibiting endogenous IGF2AS can protect anesthetic-induced neurotoxicity in neural stem cells, possibly through complimentary IGF2 upregulation and its associated downstream signaling pathways.
Title: Inhibition of long non-coding RNA IGF2AS protects apoptosis and neuronal loss in anesthetic-damaged mouse neural stem cell derived neurons.
Inhibiting endogenous IGF2AS may promote neuronal growth and protect local-anesthetic induced neurotoxicity.
Title: Inhibition of long non-coding RNA IGF2AS has profound effect on inducing neuronal growth and protecting local-anesthetic induced neurotoxicity in dorsal root ganglion neurons.
cellular localization of Igf2as transcripts together with polysome fractionation analysis provides compelling evidence that the Igf2as is protein coding
Title: The Igf2as transcript is exported into cytoplasm and associated with polysomes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

ECD21742 (e-PCR)
- UniSTS:302735

PMC125515P2 (e-PCR)
- UniSTS:270500

PMC309645P2 (e-PCR)
- UniSTS:272601

PMC309645P3 (e-PCR)
- UniSTS:272602

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.