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    Rnf121 ring finger protein 121 [ Mus musculus (house mouse) ]

    Gene ID: 75212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf121provided by MGI
    Official Full Name
    ring finger protein 121provided by MGI
    Primary source
    MGI:MGI:1922462
    See related
    Ensembl:ENSMUSG00000070426 AllianceGenome:MGI:1922462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930544L10Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human RNF121 (ring finger protein 121). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 13.4), large intestine adult (RPKM 13.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf121 in Genome Data Viewer
    Location:
    7 E2; 7 54.71 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101668344..101721712, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102019137..102072437, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8193 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene interleukin 18 binding protein Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Cheung BB, et al. Commun Biol, 2024 Oct 14. PMID 39402275, Free PMC Article
    2. The E3 ubiquitin ligase RNF121 is a positive regulator of NF-κB activation. Zemirli N, et al. Cell Commun Signal, 2014 Nov 12. PMID 25388546, Free PMC Article
    3. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis.
      Title: Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin ligase Rnf121
    NP_001347677.1
    NP_083487.2
    XP_006508338.1
    XP_030098907.1
    XP_030098908.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360748.1 → NP_001347677.1  E3 ubiquitin ligase Rnf121 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC150275, AC167240, BE946466
      Conserved Domains (1) summary
      cd16475
      Location:70 → 124
      RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

    2. NM_029211.3 → NP_083487.2  E3 ubiquitin ligase Rnf121 isoform 1

      See identical proteins and their annotated locations for NP_083487.2

      Status: VALIDATED

      Source sequence(s)
      AC167240, AK159260, BE946466, BY316785
      Consensus CDS
      CCDS21523.1
      UniProtKB/Swiss-Prot
      Q3TXH5, Q8BP06, Q8BSB1, Q8R1Z9, Q9D4X4
      UniProtKB/TrEMBL
      Q3TXY7
      Related
      ENSMUSP00000094396.6, ENSMUST00000096639.12
      Conserved Domains (1) summary
      cd16475
      Location:224 → 278
      RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101668344..101721712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508275.4 → XP_006508338.1  E3 ubiquitin ligase Rnf121 isoform X1

      See identical proteins and their annotated locations for XP_006508338.1

      UniProtKB/TrEMBL
      Q3TXY7
      Conserved Domains (2) summary
      cd16475
      Location:212 → 266
      RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
      cl28910
      Location:44 → 200
      MFS; Major Facilitator Superfamily

    2. XM_030243047.2 → XP_030098907.1  E3 ubiquitin ligase Rnf121 isoform X2

      UniProtKB/TrEMBL
      K4DI70, Q3TXY7
      Related
      ENSMUSP00000086453.5, ENSMUST00000089052.11
      Conserved Domains (1) summary
      cd16475
      Location:201 → 255
      RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

    3. XM_030243048.2 → XP_030098908.1  E3 ubiquitin ligase Rnf121 isoform X3

      Conserved Domains (1) summary
      cd16475
      Location:70 → 124
      RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1Z9.1 GenPept UniProtKB/Swiss-Prot:Q8R1Z9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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