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    Cyp2d34 cytochrome P450, family 2, subfamily d, polypeptide 34 [ Mus musculus (house mouse) ]

    Gene ID: 223706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp2d34provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily d, polypeptide 34provided by MGI
    Primary source
    MGI:MGI:2385022
    See related
    Ensembl:ENSMUSG00000094559 AllianceGenome:MGI:2385022
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward colon adult (RPKM 133.9) See more
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    Genomic context

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    See Cyp2d34 in Genome Data Viewer
    Location:
    15 E1; 15 38.66 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82500164..82505157, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82615963..82620956, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39298 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 33, pseudogene Neighboring gene STARR-seq mESC enhancer starr_39299 Neighboring gene STARR-seq mESC enhancer starr_39300 Neighboring gene STARR-seq mESC enhancer starr_39301 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 34, pseudogene Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 13 Neighboring gene cytochrome P450, family 2, subfamily d, member 35, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18824

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anandamide 11,12 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 14,15 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 8,9 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aromatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily d, polypeptide 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145474.2 → NP_663449.2  cytochrome P450, family 2, subfamily d, polypeptide 34

      Status: PROVISIONAL

      Source sequence(s)
      AC118710
      Consensus CDS
      CCDS37161.1
      UniProtKB/TrEMBL
      L7N463
      Related
      ENSMUSP00000105141.2, ENSMUST00000109515.3
      Conserved Domains (1) summary
      pfam00067
      Location:37 → 496
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82500164..82505157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316570.1 → XP_017172059.1  cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X1

      Conserved Domains (1) summary
      pfam00067
      Location:1 → 421
      p450; Cytochrome P450

    2. XM_030248505.1 → XP_030104365.1  cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X4

      Conserved Domains (1) summary
      pfam00067
      Location:37 → 511
      p450; Cytochrome P450

    3. XM_030248504.1 → XP_030104364.1  cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X2

      Conserved Domains (1) summary
      pfam00067
      Location:37 → 398
      p450; Cytochrome P450

    4. XM_017316571.2 → XP_017172060.1  cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X3

      Conserved Domains (1) summary
      pfam00067
      Location:37 → 332
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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