Axin2 axin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Axin2provided by MGI
Official Full Name: axin 2provided by MGI
Primary source: MGI:MGI:1270862
See related: Ensembl:ENSMUSG00000000142 AllianceGenome:MGI:1270862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Axi1; Axil; Conductin
Summary: Enables I-SMAD binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including heart valve morphogenesis; negative regulation of canonical Wnt signaling pathway; and regulation of centromeric sister chromatid cohesion. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; and regionalization. Located in centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); and orofacial cleft. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 14.6), limb E14.5 (RPKM 12.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 71.83 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (108808687..108841609)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (108917828..108950783)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Axin2 depletion in macrophages alleviated senescence and increased immune response after myocardial infarction.
Title: Axin2 depletion in macrophages alleviated senescence and increased immune response after myocardial infarction.
Pharmacological targeting of Axin2 suppresses cell growth and metastasis in colorectal cancer.
Title: Pharmacological targeting of Axin2 suppresses cell growth and metastasis in colorectal cancer.
miR-15b-5p transcription mediated by CREB1 protects against inflammation and apoptosis in Parkinson disease models by inhibiting AXIN2 and activating Wnt/beta-catenin.
Title: miR-15b-5p transcription mediated by CREB1 protects against inflammation and apoptosis in Parkinson disease models by inhibiting AXIN2 and activating Wnt/β-catenin.
ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy.
Title: ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy.
Axin2-CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2-expressing odontogenic cells.
Title: Axin2-CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2-expressing odontogenic cells.
BMSC-derived extracellular vesicles promoted osteogenesis via Axin2 inhibition by delivering MiR-16-5p.
Title: BMSC-derived extracellular vesicles promoted osteogenesis via Axin2 inhibition by delivering MiR-16-5p.
Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders.
Title: Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders.
Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.
Title: Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.
Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis.
Title: Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis.
Axin2-expressing cells in the periodontal ligament are regulated by bone morphogenetic protein signalling and play a pivotal role in periodontium development.
Title: Axin2-expressing cells in the periodontal ligament are regulated by bone morphogenetic protein signalling and play a pivotal role in periodontium development.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (6) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Axin2 (e-PCR), detects polymorphism
- UniSTS:526850

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IEA Inferred from Electronic Annotation more info
involved_in dorsal/ventral axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intramembranous ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	IEA Inferred from Electronic Annotation more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in maintenance of DNA repeat elements	IEA Inferred from Electronic Annotation more info
involved_in maintenance of DNA repeat elements	ISO Inferred from Sequence Orthology more info
involved_in mitral valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of centromeric sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of centromeric sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of centromeric sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of chondrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mismatch repair	IEA Inferred from Electronic Annotation more info
involved_in regulation of mismatch repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secondary heart field specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	NAS Non-traceable Author Statement more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: axin-2

Names: axin-like protein; axis inhibition protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417411.1 → NP_001404340.1 axin-2

Status: VALIDATED

Source sequence(s)

AL662893

UniProtKB/Swiss-Prot

O88566, Q6PFZ9, Q9QXJ6
NM_001417412.1 → NP_001404341.1 axin-2

Status: VALIDATED

Source sequence(s)

AL662893

UniProtKB/Swiss-Prot

O88566, Q6PFZ9, Q9QXJ6
NM_001417413.1 → NP_001404342.1 axin-2

Status: VALIDATED

Source sequence(s)

AL662893

UniProtKB/Swiss-Prot

O88566, Q6PFZ9, Q9QXJ6
NM_001417414.1 → NP_001404343.1 axin-2

Status: VALIDATED

Source sequence(s)

AL662893

UniProtKB/Swiss-Prot

O88566, Q6PFZ9, Q9QXJ6
NM_015732.4 → NP_056547.3 axin-2

See identical proteins and their annotated locations for NP_056547.3

Status: VALIDATED

Source sequence(s)

AK142333, BC057338

Consensus CDS

CCDS25575.1

UniProtKB/Swiss-Prot

O88566, Q6PFZ9, Q9QXJ6

UniProtKB/TrEMBL

Q3UQK5

Related

ENSMUSP00000051331.8, ENSMUST00000052915.14

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:758 → 840

DAX; Domain present in Dishevelled and axin

pfam08833
Location:432 → 467

Axin_b-cat_bind; Axin beta-catenin binding domain

pfam16646
Location:10 → 73

AXIN1_TNKS_BD; Axin-1 tankyrase binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

108808687..108841609

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532060.3 → XP_006532123.1 axin-2 isoform X1

See identical proteins and their annotated locations for XP_006532123.1

UniProtKB/Swiss-Prot

O88566, Q6PFZ9, Q9QXJ6

UniProtKB/TrEMBL

Q3UQK5

Related

ENSMUSP00000102322.2, ENSMUST00000106711.2

Conserved Domains (4) summary

cd08707
Location:82 → 198

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:758 → 840

DAX; Domain present in Dishevelled and axin

pfam08833
Location:432 → 467

Axin_b-cat_bind; Axin beta-catenin binding domain

pfam16646
Location:10 → 73

AXIN1_TNKS_BD; Axin-1 tankyrase binding domain