Ahrr aryl-hydrocarbon receptor repressor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ahrrprovided by MGI
Official Full Name: aryl-hydrocarbon receptor repressorprovided by MGI
Primary source: MGI:MGI:1333776
See related: Ensembl:ENSMUSG00000021575 AllianceGenome:MGI:1333776
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1234
Summary: This gene encodes a protein that represses aryl hydrocarbon receptor-dependent signaling. The encoded protein competes with the aryl hydrocarbon receptor transcription factor for heterodimerization with the aryl hydrocarbon receptor nuclear translocator protein and binding to xenobiotic response element (XRE) sequence in many genes. This protein is implicated in the regulation of cell growth and differentiation as well as mediating dioxin toxicity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Expression: Broad expression in bladder adult (RPKM 2.1), limb E14.5 (RPKM 1.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.15 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (74359237..74440450, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (74211118..74292331, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AHR Signaling Dampens Inflammatory Signature in Neonatal Skin gammadelta T Cells.
Title: AHR Signaling Dampens Inflammatory Signature in Neonatal Skin γδ T Cells.
Since AhRR knockdown increases the expression and activity of peroxisome proliferator-activated receptor gamma (PPARgamma), AhRR negatively regulates PPARgamma during adipogenesis
Title: Suppressive effects of aryl-hydrocarbon receptor repressor on adipocyte differentiation in 3T3-L1 cells.
These findings highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli. Specifically, AhRR contributes to the maintenance of colonic intraepithelial lymphocytes and prevents excessive IL-1beta production and Th17/Tc17 differentiation. In contrast, the AhRR enhances IFN-gamma-production by effector T cells in the in...
Title: Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Suggest AHRR mediates dioxin inhibition of lactation by blocking transcription of beta-casein.
Title: Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressor.
Immortalized TiPARP(-/-) mouse embryonic fibroblasts (MEFs) and AHRR(-/-) MEFs exhibited enhanced AHR transactivation.
Title: Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling.
AhRR mRNA expression pattern in untreated C57BL/6 mice varies across tissues with high levels in hearts and brains
Title: Tissue distribution and function of the Aryl hydrocarbon receptor repressor (AhRR) in C57BL/6 and Aryl hydrocarbon receptor deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ahrr (e-PCR), detects polymorphism
- UniSTS:545886

44.MMHAP22FRG11.seq (e-PCR)
- UniSTS:124529

AB015140 (e-PCR)
- UniSTS:163539

47.MHAa95d11.seq (e-PCR)
- UniSTS:124644

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aryl hydrocarbon receptor repressor

Names: ahR repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317351.1 → NP_001304280.1 aryl hydrocarbon receptor repressor isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK076306, AK155711, BY196943

Consensus CDS

CCDS84037.1

UniProtKB/Swiss-Prot

Q147Z5, Q3U1U7, Q3U3H6, Q69ZN4, Q9Z312

UniProtKB/TrEMBL

A0A0R4J1D3

Related

ENSMUSP00000105268.2, ENSMUST00000109640.8

Conserved Domains (1) summary

cd00130
Location:2 → 51

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
NM_009644.3 → NP_033774.1 aryl hydrocarbon receptor repressor isoform 1

See identical proteins and their annotated locations for NP_033774.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK076306, AK155711, BY196943

Consensus CDS

CCDS26641.1

UniProtKB/Swiss-Prot

Q147Z5, Q3U1U7, Q3U3H6, Q69ZN4, Q9Z312

UniProtKB/TrEMBL

A0A0R4J020

Related

ENSMUSP00000022059.8, ENSMUST00000022059.14

Conserved Domains (3) summary

smart00353
Location:35 → 86

HLH; helix loop helix domain

smart00091
Location:108 → 174

PAS; PAS domain

pfam00989
Location:108 → 173

PAS; PAS fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

74359237..74440450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517050.4 → XP_006517113.1 aryl hydrocarbon receptor repressor isoform X1

See identical proteins and their annotated locations for XP_006517113.1

UniProtKB/Swiss-Prot

Q147Z5, Q3U1U7, Q3U3H6, Q69ZN4, Q9Z312

UniProtKB/TrEMBL

A0A0R4J1D3

Conserved Domains (1) summary

cd00130
Location:2 → 51

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
XM_006517049.5 → XP_006517112.1 aryl hydrocarbon receptor repressor isoform X1

See identical proteins and their annotated locations for XP_006517112.1

UniProtKB/Swiss-Prot

Q147Z5, Q3U1U7, Q3U3H6, Q69ZN4, Q9Z312

UniProtKB/TrEMBL

A0A0R4J1D3

Conserved Domains (1) summary

cd00130
Location:2 → 51

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
XM_006517048.3 → XP_006517111.1 aryl hydrocarbon receptor repressor isoform X1

See identical proteins and their annotated locations for XP_006517111.1

UniProtKB/Swiss-Prot

Q147Z5, Q3U1U7, Q3U3H6, Q69ZN4, Q9Z312

UniProtKB/TrEMBL

A0A0R4J1D3

Conserved Domains (1) summary

cd00130
Location:2 → 51

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...