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    Tecta tectorin alpha [ Mus musculus (house mouse) ]

    Gene ID: 21683, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tectaprovided by MGI
    Official Full Name
    tectorin alphaprovided by MGI
    Primary source
    MGI:MGI:109575
    See related
    Ensembl:ENSMUSG00000037705 AllianceGenome:MGI:109575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tctna
    Summary
    An extracellular matrix structural constituent. Acts upstream of or within auditory receptor cell stereocilium organization. Located in extracellular matrix. Is expressed in inner ear. Used to study autosomal dominant nonsyndromic deafness 12. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Orthologous to human TECTA (tectorin alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 2.7), CNS E14 (RPKM 0.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tecta in Genome Data Viewer
    Location:
    9 A5.1; 9 23.63 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (42240918..42312986, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (42329622..42401690, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36435 Neighboring gene predicted gene, 26272 Neighboring gene STARR-seq mESC enhancer starr_23902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:42236216-42236386 Neighboring gene predicted gene, 47629 Neighboring gene STARR-seq mESC enhancer starr_23903 Neighboring gene STARR-seq mESC enhancer starr_23904 Neighboring gene STARR-positive B cell enhancer ABC_E9327 Neighboring gene tubulin folding cofactor E-like Neighboring gene predicted gene 16322 Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene predicted gene, 36590

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spontaneous Otoacoustic Emissions in Tecta(Y1870C/+) Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane. Cheatham MA, et al. eNeuro, 2018 Nov-Dec. PMID 30627650, Free PMC Article
    2. Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane. Legan PK, et al. Hum Mol Genet, 2014 May 15. PMID 24363064, Free PMC Article
    3. A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Legan PK, et al. Neuron, 2000 Oct. PMID 11087000
    4. Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti. Lee HY, et al. J Neurosci, 2016 Aug 3. PMID 27488636, Free PMC Article
    5. Role of the tectorial membrane revealed by otoacoustic emissions recorded from wild-type and transgenic Tecta(deltaENT/deltaENT) mice. Lukashkin AN, et al. J Neurophysiol, 2004 Jan. PMID 14523068

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The release of surface-anchored alpha-tectorin, an apical extracellular matrix protein, mediates tectorial membrane organization.
      Title: The release of surface-anchored α-tectorin, an apical extracellular matrix protein, mediates tectorial membrane organization.
    2. This study demonstrated that the Tecta(Y1870C/+) Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane.
      Title: Spontaneous Otoacoustic Emissions in Tecta(Y1870C/+) Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane.
    3. These results highlight the importance of the tectorin-based matrix and epithelial signals for precise collagen organisation in the tectorial membrane.
      Title: A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.
    4. Alpha-tectorin and beta-tectorin crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.
      Title: Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.
    5. Tecta mutant mice all exhibit an enhanced tendency to have audiogenic seizures in response to white noise stimuli.
      Title: Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane.
    6. CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane
      Title: Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
    7. The morphology and mechanical properties of wild-type, heterozygous, and homozygous Tecta tecta membrane, were analysed.
      Title: Structural and mechanical analysis of tectorial membrane Tecta mutants.
    8. In Tecta(Y)(1870C/+) mice, the tectorin content of the tectorial membrane was reduced, as was the content of glycoconjugates reacting with the lectin wheat germ agglutinin.
      Title: Tectorial membrane material properties in Tecta(Y)(1870C/+) heterozygous mice.
    9. The Tecta (A349D/A349D) mouse reveals that missense mutations in Tecta can be recessive and lead to tectorial membrane detachment
      Title: Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix structural constituent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix structural constituent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auditory receptor cell stereocilium organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-tectorin
    Names
    [a]-tectorin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324548.2 → NP_001311477.1  alpha-tectorin isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC156631
      Consensus CDS
      CCDS85660.1
      UniProtKB/TrEMBL
      B7ZWA6
      Related
      ENSMUSP00000125370.2, ENSMUST00000160940.2
      Conserved Domains (10) summary
      smart00216
      Location:703 → 865
      VWD; von Willebrand factor (vWF) type D domain
      smart00241
      Location:1800 → 2054
      ZP; Zona pellucida (ZP) domain
      smart00539
      Location:98 → 254
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      smart00832
      Location:517 → 591
      C8; This domain contains 8 conserved cysteine residues
      pfam00094
      Location:322 → 478
      VWD; von Willebrand factor type D domain
      pfam00100
      Location:1932 → 2052
      Zona_pellucida; Zona pellucida-like domain
      pfam01826
      Location:597 → 650
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1298 → 1368
      C8; C8 domain
      pfam14670
      Location:2084 → 2116
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl17735
      Location:652 → 706
      VWC; von Willebrand factor type C domain

    2. NM_001378602.1 → NP_001365531.1  alpha-tectorin isoform 1 prepreprotein precursor

      Status: VALIDATED

      Source sequence(s)
      AC156631
      UniProtKB/Swiss-Prot
      E9QNR3, O08523
      UniProtKB/TrEMBL
      B7ZWA6
      Conserved Domains (9) summary
      smart00216
      Location:703 → 865
      VWD; von Willebrand factor (vWF) type D domain
      smart00241
      Location:1805 → 2059
      ZP; Zona pellucida (ZP) domain
      smart00539
      Location:98 → 254
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      smart00832
      Location:517 → 591
      C8; This domain contains 8 conserved cysteine residues
      cl17735
      Location:652 → 706
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:322 → 478
      VWD; von Willebrand factor type D domain
      pfam08742
      Location:1300 → 1368
      C8; C8 domain
      pfam14670
      Location:2089 → 2121
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cd19941
      Location:597 → 650
      TIL; trypsin inhibitor-like cysteine rich domain

    3. NM_009347.4 → NP_033373.2  alpha-tectorin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_033373.2

      Status: VALIDATED

      Source sequence(s)
      AC156631
      Consensus CDS
      CCDS23087.1
      UniProtKB/Swiss-Prot
      E9QNR3, O08523
      UniProtKB/TrEMBL
      B7ZWA6
      Related
      ENSMUSP00000040262.8, ENSMUST00000042190.14
      Conserved Domains (9) summary
      smart00216
      Location:703 → 865
      VWD; von Willebrand factor (vWF) type D domain
      smart00241
      Location:1805 → 2059
      ZP; Zona pellucida (ZP) domain
      smart00539
      Location:98 → 254
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      smart00832
      Location:517 → 591
      C8; This domain contains 8 conserved cysteine residues
      cl17735
      Location:652 → 706
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:322 → 478
      VWD; von Willebrand factor type D domain
      pfam08742
      Location:1300 → 1368
      C8; C8 domain
      pfam14670
      Location:2089 → 2121
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cd19941
      Location:597 → 650
      TIL; trypsin inhibitor-like cysteine rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      42240918..42312986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154833.1 → XP_036010726.1  alpha-tectorin isoform X1

      UniProtKB/TrEMBL
      B7ZWA6
      Conserved Domains (9) summary
      smart00216
      Location:676 → 838
      VWD; von Willebrand factor (vWF) type D domain
      smart00241
      Location:1778 → 2032
      ZP; Zona pellucida (ZP) domain
      smart00539
      Location:71 → 227
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      smart00832
      Location:490 → 564
      C8; This domain contains 8 conserved cysteine residues
      cl17735
      Location:625 → 679
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:295 → 451
      VWD; von Willebrand factor type D domain
      pfam08742
      Location:1273 → 1341
      C8; C8 domain
      pfam14670
      Location:2062 → 2094
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cd19941
      Location:570 → 623
      TIL; trypsin inhibitor-like cysteine rich domain

    2. XM_006510152.3 → XP_006510215.1  alpha-tectorin isoform X2

      UniProtKB/TrEMBL
      B7ZWA6
      Conserved Domains (7) summary
      smart00216
      Location:703 → 865
      VWD; von Willebrand factor (vWF) type D domain
      smart00539
      Location:98 → 254
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      smart00832
      Location:517 → 591
      C8; This domain contains 8 conserved cysteine residues
      cl17735
      Location:652 → 706
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:322 → 476
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:597 → 650
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1301 → 1368
      C8; C8 domain

    RNA

    1. XR_004935379.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08523.2 GenPept UniProtKB/Swiss-Prot:O08523

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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