Fnta farnesyltransferase, CAAX box, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fntaprovided by MGI
Official Full Name: farnesyltransferase, CAAX box, alphaprovided by MGI
Primary source: MGI:MGI:104683
See related: Ensembl:ENSMUSG00000015994 AllianceGenome:MGI:104683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FTA
Summary: Enables Rab geranylgeranyltransferase activity; protein farnesyltransferase activity; and receptor tyrosine kinase binding activity. Involved in enzyme-linked receptor protein signaling pathway; positive regulation of Rac protein signal transduction; and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Predicted to be part of CAAX-protein geranylgeranyltransferase complex; microtubule associated complex; and protein farnesyltransferase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; brain; hemolymphoid system gland; and reproductive system. Orthologous to human FNTA (farnesyltransferase, CAAX box, subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 19.6), bladder adult (RPKM 17.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 14.27 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (26488716..26505638, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (25998688..26015610, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Title: Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion.
Title: Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fnta (e-PCR), detects polymorphism
- UniSTS:143123

D8Rck2 (e-PCR), detects polymorphism
- UniSTS:142728

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CAAX-protein geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to CAAX-protein geranylgeranyltransferase activity	ISO Inferred from Sequence Orthology more info
enables Rab geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
contributes_to heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
contributes_to peptide binding	ISO Inferred from Sequence Orthology more info
contributes_to protein farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein farnesyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to protein farnesyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein farnesyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein geranylgeranyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein geranylgeranyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein geranylgeranyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to small molecule binding	ISO Inferred from Sequence Orthology more info
contributes_to zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in enzyme-linked receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in peptide pheromone maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of deacetylase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tubulin deacetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein farnesylation	ISO Inferred from Sequence Orthology more info
involved_in protein farnesylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein geranylgeranylation	ISO Inferred from Sequence Orthology more info
involved_in protein geranylgeranylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CAAX-protein geranylgeranyltransferase complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of CAAX-protein geranylgeranyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
part_of protein farnesyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein farnesyltransferase complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein farnesyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Names: CAAX farnesyltransferase subunit alpha; FTase-alpha; GGTase-I-alpha; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase subunit alpha

NP_032059.1

EC 2.5.1.58

EC 2.5.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008033.4 → NP_032059.1 protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

See identical proteins and their annotated locations for NP_032059.1

Status: VALIDATED

Source sequence(s)

AC093366

Consensus CDS

CCDS22205.1

UniProtKB/Swiss-Prot

Q61239, Q921F7

UniProtKB/TrEMBL

Q541Z2

Related

ENSMUSP00000016138.10, ENSMUST00000016138.11

Conserved Domains (1) summary

PLN02789
Location:64 → 365

PLN02789; farnesyltranstransferase