ZGLP1 zinc finger GATA like protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZGLP1provided by HGNC
Official Full Name: zinc finger GATA like protein 1provided by HGNC
Primary source: HGNC:HGNC:37245
See related: Ensembl:ENSG00000220201 MIM:611639; AllianceGenome:HGNC:37245
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLP1; GLP-1; GATAD3
Summary: ZGLP1 encodes an evolutionary conserved transcriptional regulator with GATA-like zinc fingers. In females, it is expressed in embryonic germ cells and is essential for oogenic fate determination. It acts downstream of bone morphogenetic protein (BMP) and is involved in the regulation of genes involved in RNA processing, transcription and chromatin modification, retrotransposon regulation, meiotic cell cycle, and oocyte development. In males it is not required for the germ cell sex determination but is required by the spermatogonia for efficiently completing the meiotic prophase. [provided by RefSeq, Jul 2022]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression: Ubiquitous expression in testis (RPKM 1.4), spleen (RPKM 0.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (10304803..10309815, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (10430915..10435928, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (10415479..10420491, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is minor contribution of endogenous GLP-1 and GLP-2 to postprandial lipemia in obese men.
Title: Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men.
Characterization and functional analysis of the mouse GLP-1 ortholog, and comparison to the human protein.
Title: GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

RH48407 (e-PCR)
- UniSTS:15400

RH93808 (e-PCR)
- UniSTS:85367

Readthrough FDX2-ZGLP1

Readthrough gene: FDX2-ZGLP1, Included gene: FDX2

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in oocyte development	IBA Inferred from Biological aspect of Ancestor more info
involved_in oocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GATA-type zinc finger protein 1

Names: GATA zinc finger domain containing 3; GATA-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103167.1 → NP_001096637.1 GATA-type zinc finger protein 1 isoform 1

See identical proteins and their annotated locations for NP_001096637.1

Status: VALIDATED

Source sequence(s)

BC029904, CK826281

Consensus CDS

CCDS45959.1

Conserved Domains (2) summary

smart00401
Location:202 → 240

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

pfam00320
Location:206 → 240

GATA; GATA zinc finger
NM_001409033.1 → NP_001395962.1 GATA-type zinc finger protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC011511

UniProtKB/Swiss-Prot

A0A9L9PXT6, P0C6A0

Related

ENSP00000516709.1, ENST00000707000.1