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    MSR1 macrophage scavenger receptor 1 [ Homo sapiens (human) ]

    Gene ID: 4481, updated on 10-Dec-2024

    Summary

    Official Symbol
    MSR1provided by HGNC
    Official Full Name
    macrophage scavenger receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:7376
    See related
    Ensembl:ENSG00000038945 MIM:153622; AllianceGenome:HGNC:7376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII
    Summary
    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung (RPKM 26.5), gall bladder (RPKM 9.7) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MSR1 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (16107881..16192651, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (16374329..16459913, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (15965390..16050160, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene tumor suppressor candidate 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:15714775-15714991 Neighboring gene MPRA-validated peak6918 silencer Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1A pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:15851888-15852590 Neighboring gene ribosomal protein L32 pseudogene 19 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:16060074-16060578 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:16141012-16141954 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:16141955-16142895 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:16152188-16152760 Neighboring gene uncharacterized LOC101929028 Neighboring gene chaperonin containing TCP1 subunit 3 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L49 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amyloid-beta binding  
    enables amyloid-beta binding  
    enables cargo receptor activity  
    enables low-density lipoprotein particle binding  
    enables low-density lipoprotein particle binding PubMed 
    enables protein binding PubMed 
    enables scavenger receptor activity PubMed 
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance  
    involved_in amyloid-beta clearance  
    involved_in cellular response to organic cyclic compound  
    involved_in cholesterol transport PubMed 
    involved_in establishment of localization in cell  
    involved_in lipoprotein transport  
    involved_in negative regulation of gene expression  
    involved_in phagocytosis, engulfment  
    involved_in plasma lipoprotein particle clearance  
    involved_in plasma lipoprotein particle clearance PubMed 
    involved_in positive regulation of cholesterol storage  
    involved_in positive regulation of cholesterol storage  
    involved_in positive regulation of macrophage derived foam cell differentiation PubMed 
    involved_in receptor-mediated endocytosis  
    involved_in receptor-mediated endocytosis PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer  
    located_in endocytic vesicle membrane  
    part_of low-density lipoprotein particle  
    located_in membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    macrophage scavenger receptor types I and II
    Names
    macrophage acetylated LDL receptor I and II
    macrophage scavenger receptor type III
    scavenger receptor class A member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012102.1 RefSeqGene

      Range
      5141..89911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363744.1 → NP_001350673.1  macrophage scavenger receptor types I and II isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC023396, AK293217, BC063878
      Consensus CDS
      CCDS87581.1
      UniProtKB/TrEMBL
      B4DDJ5
      Related
      ENSP00000405453.2, ENST00000445506.6
      Conserved Domains (4) summary
      pfam01391
      Location:298 → 352
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:368 → 468
      SR; Scavenger receptor Cys-rich
      pfam03523
      Location:139 → 187
      Macscav_rec; Macrophage scavenger receptor
      cl26252
      Location:122 → 287
      AAA_13; AAA domain
    2. NM_002445.4 → NP_002436.1  macrophage scavenger receptor types I and II isoform type 2

      See identical proteins and their annotated locations for NP_002436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AII), also known as phSR2, uses two alternative exons and also lacks two downstream exons compared to variant SR-AI. These differences causes an alternate 3' end in the coding region, and has a distinct 3' UTR. It encodes isoform type 2 that is shorter and has a different C-terminus than isoform type 1.
      Source sequence(s)
      AC023396, D90188
      Consensus CDS
      CCDS5997.1
      UniProtKB/Swiss-Prot
      P21757
      Related
      ENSP00000371428.4, ENST00000381998.8
      Conserved Domains (2) summary
      pfam01391
      Location:280 → 334
      Collagen; Collagen triple helix repeat (20 copies)
      pfam03523
      Location:121 → 169
      Macscav_rec; Macrophage scavenger receptor
    3. NM_138715.3 → NP_619729.1  macrophage scavenger receptor types I and II isoform type 1

      See identical proteins and their annotated locations for NP_619729.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AI), also known as phSR1, encodes the longest isoform.
      Source sequence(s)
      AC023396, D90187, DA995755
      Consensus CDS
      CCDS5995.1
      UniProtKB/Swiss-Prot
      D3DSP3, O60505, P21757, P21759, Q45F10
      Related
      ENSP00000262101.5, ENST00000262101.10
      Conserved Domains (4) summary
      pfam01391
      Location:280 → 334
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:350 → 450
      SR; Scavenger receptor Cys-rich
      pfam03523
      Location:121 → 169
      Macscav_rec; Macrophage scavenger receptor
      cl26252
      Location:104 → 269
      AAA_13; AAA domain
    4. NM_138716.3 → NP_619730.1  macrophage scavenger receptor types I and II isoform type 3

      See identical proteins and their annotated locations for NP_619730.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (SR-AIII) lacks an exon in the coding region, but maintains the same reading frame, as compared to variant SR-AI. It encodes an isoform type 3 that lacks 63 internal amino acids compared to isoform type 1.
      Source sequence(s)
      AC023396, D90187, DA995755
      Consensus CDS
      CCDS5996.1
      UniProtKB/Swiss-Prot
      P21757
      Related
      ENSP00000262100.3, ENST00000350896.3
      Conserved Domains (4) summary
      pfam01391
      Location:280 → 334
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:346 → 387
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:318 → 387
      SRCR; Scavenger receptor cysteine-rich domain
      pfam03523
      Location:121 → 169
      Macscav_rec; Macrophage scavenger receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      16107881..16192651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447161.2 → XP_024302929.1  macrophage scavenger receptor types I and II isoform X1

      Conserved Domains (3) summary
      pfam01391
      Location:298 → 352
      Collagen; Collagen triple helix repeat (20 copies)
      pfam03523
      Location:139 → 187
      Macscav_rec; Macrophage scavenger receptor
      cl26252
      Location:122 → 287
      AAA_13; AAA domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      16374329..16459913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360498.1 → XP_054216473.1  macrophage scavenger receptor types I and II isoform X1

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