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    MEF2D myocyte enhancer factor 2D [ Homo sapiens (human) ]

    Gene ID: 4209, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MEF2Dprovided by HGNC
    Official Full Name
    myocyte enhancer factor 2Dprovided by HGNC
    Primary source
    HGNC:HGNC:6997
    See related
    Ensembl:ENSG00000116604 MIM:600663; AllianceGenome:HGNC:6997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
    Expression
    Ubiquitous expression in bone marrow (RPKM 18.8), brain (RPKM 15.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MEF2D in Genome Data Viewer
    Location:
    1q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156463727..156500775, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155602298..155639356, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156433519..156470567, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156362688-156363193 Neighboring gene Rh family B glycoprotein Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156369951-156370626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156371301-156371974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156382372-156382872 Neighboring gene MIR9-1 host gene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156390239-156390770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156391951-156392452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1427 Neighboring gene microRNA 9-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:156409392-156409986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156409987-156410580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156418512-156419012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156426495-156427452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156427509-156428010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156428011-156428510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156431759-156432710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156432711-156433660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156445026-156445638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156466171-156466671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156471045-156471824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1868 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156474933-156475335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1869 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156483472-156483678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1430 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:156495835-156496406 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:156508711-156509291 Neighboring gene IQ motif containing GTPase activating protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554411-156554912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554913-156555412 Neighboring gene tetratricopeptide repeat domain 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes. Ma L, et al. Cancer Res, 2014 Mar 1. PMID 24390737
    2. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Breitbart RE, et al. Development, 1993 Aug. PMID 8269842
    3. [Expression of MEF2D on nasopharyngeal carcinoma tissues and its influence of prognostic]. Li Y, et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2011 Sep. PMID 22256741
    4. Loss of MEF2D expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cells. Zhang M, et al. Mol Cancer, 2013 Nov 27. PMID 24279793, Free PMC Article
    5. miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D. Cao Q, et al. Oncol Rep, 2015 May. PMID 25812649

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation.
      Title: MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation.
    2. Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
      Title: Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
    3. Myxoid epithelioid smooth muscle tumor of the vulva: A distinct entity with MEF2D::NCOA2 gene fusion.
      Title: Myxoid epithelioid smooth muscle tumor of the vulva: A distinct entity with MEF2D::NCOA2 gene fusion.
    4. A Ubiquitin-Dependent Switch on MEF2D Senses Pro-Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer.
      Title: A Ubiquitin-Dependent Switch on MEF2D Senses Pro-Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer.
    5. [Clinical characteristics and outcomes of childhood B-ALL with ZNF384 and MEF2D rearrangements].
      Title: [Clinical characteristics and outcomes of childhood B-ALL with ZNF384 and MEF2D rearrangements].
    6. The transcription factor Mef2d regulates B:T synapse-dependent GC-TFH differentiation and IL-21-mediated humoral immunity.
      Title: The transcription factor Mef2d regulates B:T synapse-dependent GC-T(FH) differentiation and IL-21-mediated humoral immunity.
    7. Dysregulation of Kruppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.
      Title: Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.
    8. KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D.
      Title: KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D.
    9. Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance.
      Title: Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance.
    10. Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia.
      Title: Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia.
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies susceptibility loci for migraine without aura.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686I1536

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endochondral ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle organ development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myocyte-specific enhancer factor 2D
    Names
    MADS box transcription enhancer factor 2, polypeptide D

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271629.2 → NP_001258558.1  myocyte-specific enhancer factor 2D isoform 2

      See identical proteins and their annotated locations for NP_001258558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon and splice site in the 5' UTR, and lacks an internal in-frame exon in the coding region, compared to variant 1. The resulting isoform (2, also known as hMEF2Da0), is shorter than isoform 1.
      Source sequence(s)
      AL139412, BC040949, R42560
      Consensus CDS
      CCDS60304.1
      UniProtKB/TrEMBL
      Q4LE66
      Related
      ENSP00000353803.3, ENST00000360595.7
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:98 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    2. NM_005920.4 → NP_005911.1  myocyte-specific enhancer factor 2D isoform 1

      See identical proteins and their annotated locations for NP_005911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as hMEF2Dab).
      Source sequence(s)
      AL139412, BC054520, DC377787, R42560
      Consensus CDS
      CCDS1143.1
      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66
      Related
      ENSP00000271555.5, ENST00000348159.9
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156463727..156500775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421004.1 → XP_047276960.1  myocyte-specific enhancer factor 2D isoform X2

      UniProtKB/TrEMBL
      Q4LE66

    2. XM_047421009.1 → XP_047276965.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    3. XM_005245169.5 → XP_005245226.1  myocyte-specific enhancer factor 2D isoform X1

      See identical proteins and their annotated locations for XP_005245226.1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    4. XM_006711334.4 → XP_006711397.1  myocyte-specific enhancer factor 2D isoform X4

      UniProtKB/TrEMBL
      Q4LE66
      Related
      ENSP00000476788.1, ENST00000464356.6
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:96 → 151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    5. XM_006711332.4 → XP_006711395.1  myocyte-specific enhancer factor 2D isoform X2

      UniProtKB/TrEMBL
      Q4LE66
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:96 → 151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    6. XM_006711333.3 → XP_006711396.1  myocyte-specific enhancer factor 2D isoform X3

      See identical proteins and their annotated locations for XP_006711396.1

      UniProtKB/TrEMBL
      Q4LE66
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:98 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    7. XM_017001315.2 → XP_016856804.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:98 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    8. XM_006711330.4 → XP_006711393.1  myocyte-specific enhancer factor 2D isoform X1

      See identical proteins and their annotated locations for XP_006711393.1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    9. XM_047421002.1 → XP_047276958.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    10. XM_047420999.1 → XP_047276955.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    11. XM_047421005.1 → XP_047276961.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    12. XM_005245170.4 → XP_005245227.1  myocyte-specific enhancer factor 2D isoform X1

      See identical proteins and their annotated locations for XP_005245227.1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    13. XM_047420994.1 → XP_047276950.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    14. XM_047420993.1 → XP_047276949.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    15. XM_047420998.1 → XP_047276954.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    16. XM_047420997.1 → XP_047276953.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    17. XM_047420995.1 → XP_047276951.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    18. XM_017001314.2 → XP_016856803.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:98 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    19. XM_011509569.4 → XP_011507871.1  myocyte-specific enhancer factor 2D isoform X1

      See identical proteins and their annotated locations for XP_011507871.1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam12347
      Location:97 → 152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    20. XM_047421015.1 → XP_047276971.1  myocyte-specific enhancer factor 2D isoform X5

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791758.1 Reference GRCh38.p14 PATCHES

      Range
      22284..59332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332846.1 → XP_054188821.1  myocyte-specific enhancer factor 2D isoform X2

      UniProtKB/TrEMBL
      Q4LE66

    2. XM_054332851.1 → XP_054188826.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    3. XM_054332841.1 → XP_054188816.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    4. XM_054332852.1 → XP_054188827.1  myocyte-specific enhancer factor 2D isoform X4

      UniProtKB/TrEMBL
      Q4LE66

    5. XM_054332845.1 → XP_054188820.1  myocyte-specific enhancer factor 2D isoform X2

      UniProtKB/TrEMBL
      Q4LE66

    6. XM_054332847.1 → XP_054188822.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    7. XM_054332850.1 → XP_054188825.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    8. XM_054332842.1 → XP_054188817.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    9. XM_054332843.1 → XP_054188818.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    10. XM_054332849.1 → XP_054188824.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    11. XM_054332844.1 → XP_054188819.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    12. XM_054332848.1 → XP_054188823.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    13. XM_054332853.1 → XP_054188828.1  myocyte-specific enhancer factor 2D isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155602298..155639356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336657.1 → XP_054192632.1  myocyte-specific enhancer factor 2D isoform X2

      UniProtKB/TrEMBL
      Q4LE66

    2. XM_054336662.1 → XP_054192637.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    3. XM_054336652.1 → XP_054192627.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    4. XM_054336663.1 → XP_054192638.1  myocyte-specific enhancer factor 2D isoform X4

      UniProtKB/TrEMBL
      Q4LE66

    5. XM_054336656.1 → XP_054192631.1  myocyte-specific enhancer factor 2D isoform X2

      UniProtKB/TrEMBL
      Q4LE66

    6. XM_054336658.1 → XP_054192633.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    7. XM_054336661.1 → XP_054192636.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    8. XM_054336653.1 → XP_054192628.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    9. XM_054336654.1 → XP_054192629.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    10. XM_054336660.1 → XP_054192635.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    11. XM_054336655.1 → XP_054192630.1  myocyte-specific enhancer factor 2D isoform X1

      UniProtKB/Swiss-Prot
      D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
      UniProtKB/TrEMBL
      Q4LE66

    12. XM_054336659.1 → XP_054192634.1  myocyte-specific enhancer factor 2D isoform X3

      UniProtKB/TrEMBL
      Q4LE66

    13. XM_054336664.1 → XP_054192639.1  myocyte-specific enhancer factor 2D isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14814.1 GenPept UniProtKB/Swiss-Prot:Q14814

    Gene LinkOut

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