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    CENPL centromere protein L [ Homo sapiens (human) ]

    Gene ID: 91687, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CENPLprovided by HGNC
    Official Full Name
    centromere protein Lprovided by HGNC
    Primary source
    HGNC:HGNC:17879
    See related
    Ensembl:ENSG00000120334 MIM:611503; AllianceGenome:HGNC:17879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CENP-L; C1orf155; dJ383J4.3
    Summary
    CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 4.2), bone marrow (RPKM 2.4) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CENPL in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173799550..173824883, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173157718..173183047, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173768688..173794021, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 20 Neighboring gene ribosomal protein S27 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:173728073-173728573 Neighboring gene RN7SK pseudogene 160 Neighboring gene MPRA-validated peak463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2116 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:173793515-173794033 and GRCh37_chr1:173794034-173794551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:173795193-173795706 Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:173821280-173822182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830052-173830768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830769-173831485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1556 Neighboring gene GAS5 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 81 Neighboring gene growth arrest specific 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma. He K, et al. Int J Biochem Cell Biol, 2024 Jan. PMID 37914022
    2. Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma. Zeng Z, et al. Aging (Albany NY), 2021 Oct 4. PMID 34607313, Free PMC Article
    3. High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients. Cui Z, et al. Dis Markers, 2021. PMID 34457090, Free PMC Article
    4. Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients. Cui Z, et al. BMC Cancer, 2022 Dec 26. PMID 36572856, Free PMC Article
    5. The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface. McKinley KL, et al. Mol Cell, 2015 Dec 17. PMID 26698661, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma.
      Title: CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma.
    2. Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients.
      Title: Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients.
    3. Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma.
      Title: Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma.
    4. High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients.
      Title: High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients.
    5. Study demonstrate that the CENP-L-N complex plays a crucial role at the core of the 16-subunit Constitutive Centromere-Associated Network through interactions with CENP-C and CENP-H-I-KM.
      Title: The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31044, FLJ31786

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of inner kinetochore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein L
    Names
    interphase centromere complex protein 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127181.3 → NP_001120653.1  centromere protein L isoform 1

      See identical proteins and their annotated locations for NP_001120653.1

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS44277.1
      UniProtKB/Swiss-Prot
      Q8N0S6
      Related
      ENSP00000348527.2, ENST00000356198.6
      Conserved Domains (1) summary
      pfam13092
      Location:223 → 369
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    2. NM_001171182.2 → NP_001164653.1  centromere protein L isoform 2

      See identical proteins and their annotated locations for NP_001164653.1

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS30938.1
      UniProtKB/Swiss-Prot
      Q5TEL5, Q8N0S6, Q96ND4
      Related
      ENSP00000323543.7, ENST00000345664.10
      Conserved Domains (1) summary
      pfam13092
      Location:177 → 323
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    3. NM_001387284.1 → NP_001374213.1  centromere protein L isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS44277.1
      Conserved Domains (1) summary
      pfam13092
      Location:223 → 369
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    4. NM_001387285.1 → NP_001374214.1  centromere protein L isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS44277.1
      Conserved Domains (1) summary
      pfam13092
      Location:223 → 369
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    5. NM_001387286.1 → NP_001374215.1  centromere protein L isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS44277.1
      Conserved Domains (1) summary
      pfam13092
      Location:223 → 369
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    6. NM_001387287.1 → NP_001374216.1  centromere protein L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS30938.1
      UniProtKB/Swiss-Prot
      Q5TEL5, Q8N0S6, Q96ND4
      Related
      ENSP00000507473.1, ENST00000682279.1
      Conserved Domains (1) summary
      pfam13092
      Location:177 → 323
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    7. NM_001387288.1 → NP_001374217.1  centromere protein L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS30938.1
      UniProtKB/Swiss-Prot
      Q5TEL5, Q8N0S6, Q96ND4
      Conserved Domains (1) summary
      pfam13092
      Location:177 → 323
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    8. NM_001387289.1 → NP_001374218.1  centromere protein L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS30938.1
      UniProtKB/Swiss-Prot
      Q5TEL5, Q8N0S6, Q96ND4
      Conserved Domains (1) summary
      pfam13092
      Location:177 → 323
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    9. NM_001387290.1 → NP_001374219.1  centromere protein L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS30938.1
      UniProtKB/Swiss-Prot
      Q5TEL5, Q8N0S6, Q96ND4
      Conserved Domains (1) summary
      pfam13092
      Location:177 → 323
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    10. NM_001387291.1 → NP_001374220.1  centromere protein L isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Conserved Domains (1) summary
      pfam13092
      Location:155 → 301
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    11. NM_001387292.1 → NP_001374221.1  centromere protein L isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL109921

    12. NM_001387293.1 → NP_001374222.1  centromere protein L isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL109921

    13. NM_033319.4 → NP_201576.1  centromere protein L isoform 2

      See identical proteins and their annotated locations for NP_201576.1

      Status: VALIDATED

      Source sequence(s)
      AL109921
      Consensus CDS
      CCDS30938.1
      UniProtKB/Swiss-Prot
      Q5TEL5, Q8N0S6, Q96ND4
      Related
      ENSP00000356683.3, ENST00000367710.7
      Conserved Domains (1) summary
      pfam13092
      Location:177 → 323
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    RNA

    1. NR_170626.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL109921

    2. NR_170627.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL109921

    3. NR_170628.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL109921

    4. NR_170629.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL109921

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      173799550..173824883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      173157718..173183047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N0S6.2 GenPept UniProtKB/Swiss-Prot:Q8N0S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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