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    LINC00189 long intergenic non-protein coding RNA 189 [ Homo sapiens (human) ]

    Gene ID: 193629, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00189provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 189provided by HGNC
    Primary source
    HGNC:HGNC:18461
    See related
    Ensembl:ENSG00000215533 AllianceGenome:HGNC:18461
    Gene type
    ncRNA
    RefSeq status
    PREDICTED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C21orf109; NCRNA00189
    Expression
    Broad expression in placenta (RPKM 1.2), heart (RPKM 0.5) and 16 other tissues See more
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    Genomic context

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    See LINC00189 in Genome Data Viewer
    Location:
    21q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (29193494..29288205)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (27559756..27654119)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30565815..30660526)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene MAP3K7 C-terminal like Neighboring gene NANOG hESC enhancer GRCh37_chr21:30506062-30506608 Neighboring gene ribosomal protein L12 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 14833 Neighboring gene uncharacterized LOC105372767 Neighboring gene small nucleolar RNA U3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18341 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:30568347-30569546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18346 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18347 Neighboring gene uncharacterized LOC124905007 Neighboring gene uncharacterized LOC105369299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18348 Neighboring gene Sharpr-MPRA regulatory region 12458 Neighboring gene BTB domain and CNC homolog 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:30714441-30715640

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. Jiang J, et al. Front Genet, 2013. PMID 24009623, Free PMC Article
    2. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. Gardiner K, et al. Genomics, 2002 Jun. PMID 12036298
    3. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Fogeron ML, et al. Nat Commun, 2013. PMID 23443559
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: BACH1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027072.2 RNA Sequence

      Status: PREDICTED

      Source sequence(s)
      BC065252
      Related
      ENST00000420364.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      29193494..29288205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791813.1 Reference GRCh38.p14 PATCHES

      Range
      287385..288152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      27559756..27654119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138968.1: Suppressed sequence

      Description
      NM_138968.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

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