Prorsd1 prolyl-tRNA synthetase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prorsd1provided by MGI
Official Full Name: prolyl-tRNA synthetase domain containing 1provided by MGI
Primary source: MGI:MGI:1915189
See related: Ensembl:ENSMUSG00000032673 AllianceGenome:MGI:1915189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prdxdd1; Ncrna00117; 2010316F05Rik
Summary: Predicted to enable aminoacyl-tRNA editing activity. Predicted to be involved in aminoacyl-tRNA metabolism involved in translational fidelity. Is expressed in pancreas primordium dorsal bud. Orthologous to human PRORSD1P (prolyl-tRNA synthetase associated domain containing 1, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 4.0), liver E14 (RPKM 3.0) and 23 other tissues See more
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Genomic context

Location:: 11 A3.3; 11 16.75 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (29461757..29465033, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (29511757..29515033, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminoacyl-tRNA editing activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: prolyl-tRNA synthetase associated domain-containing protein 1

Names: PrdX-deacylase domain 1; prdX deacylase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163454.2 → NP_001156926.1 prolyl-tRNA synthetase associated domain-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).

Source sequence(s)

AK008574, AK077280, AK085965

Consensus CDS

CCDS48762.1

UniProtKB/TrEMBL

A0A0A0MQH9

Related

ENSMUSP00000117933.2, ENSMUST00000133103.2
NM_026465.3 → NP_080741.1 prolyl-tRNA synthetase associated domain-containing protein 1 isoform 2

See identical proteins and their annotated locations for NP_080741.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK008574, AK085965

Consensus CDS

CCDS24495.1

UniProtKB/Swiss-Prot

Q8BFX7, Q9D820

Related

ENSMUSP00000048099.4, ENSMUST00000039900.4

Conserved Domains (1) summary

cd04335
Location:7 → 166

PrdX_deacylase; This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the ...