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    Ubap2l ubiquitin-associated protein 2-like [ Mus musculus (house mouse) ]

    Gene ID: 74383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubap2lprovided by MGI
    Official Full Name
    ubiquitin-associated protein 2-likeprovided by MGI
    Primary source
    MGI:MGI:1921633
    See related
    Ensembl:ENSMUSG00000042520 AllianceGenome:MGI:1921633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nice-4; mKIAA0144; 3110083O19Rik; 4932431F02Rik; A430103N23Rik
    Summary
    Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in chromosome and cytoplasmic stress granule. Predicted to be part of PcG protein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in lung epithelium. Orthologous to human UBAP2L (ubiquitin associated protein 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 19.2), testis adult (RPKM 17.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubap2l in Genome Data Viewer
    Location:
    3 F1; 3 39.19 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89906896..89959867, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89999589..90052609, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene aquaporin 10, pseudogene Neighboring gene predicted gene, 24046 Neighboring gene STARR-positive B cell enhancer ABC_E4557 Neighboring gene predicted gene, 19710 Neighboring gene HCLS1 associated X-1 Neighboring gene predicted gene, 24608 Neighboring gene microRNA 7669 Neighboring gene RIKEN cDNA 4933434E20 gene Neighboring gene STARR-seq mESC enhancer starr_08270 Neighboring gene cilia and flagella associated protein 141 Neighboring gene microRNA 190b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of ubiquitin associated protein 2-like inhibits the growth and migration of prostate cancer cells. Li D, et al. Oncol Rep, 2014 Oct. PMID 25069639
    2. UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis. Aucagne R, et al. FASEB J, 2017 Nov. PMID 28754713
    3. Three-dimensional microCT imaging of mouse heart development from early post-implantation to late fetal stages. Li-Villarreal N, et al. Mamm Genome, 2023 Jun. PMID 36595063, Free PMC Article
    4. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Bordeleau ME, et al. Blood, 2014 Oct 9. PMID 25185265, Free PMC Article
    5. lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins. Kuniyoshi H, et al. Genetics, 2002 Dec. PMID 12524348, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25504

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated protein 2-like
    Names
    Nice-4 protein homolog
    RNA polymerase II degradation factor Ubap2l

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165983.2 → NP_001159455.1  ubiquitin-associated protein 2-like isoform 3

      See identical proteins and their annotated locations for NP_001159455.1

      Status: VALIDATED

      Source sequence(s)
      AC163616, AK048286, BM124250, CK344187
      Consensus CDS
      CCDS50966.1
      UniProtKB/TrEMBL
      Q812D5
      Related
      ENSMUSP00000066138.9, ENSMUST00000064639.15
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:521 → 548
      DUF3697; Ubiquitin-associated protein 2

    2. NM_001165984.1 → NP_001159456.1  ubiquitin-associated protein 2-like isoform 4

      See identical proteins and their annotated locations for NP_001159456.1

      Status: VALIDATED

      Source sequence(s)
      AK048286, BB842333, BC050910
      Consensus CDS
      CCDS79960.1
      UniProtKB/Swiss-Prot
      Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6
      UniProtKB/TrEMBL
      Q812D5
      Related
      ENSMUSP00000143459.2, ENSMUST00000196843.5
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:516 → 543
      DUF3697; Ubiquitin-associated protein 2

    3. NM_001165985.2 → NP_001159457.1  ubiquitin-associated protein 2-like isoform 5

      See identical proteins and their annotated locations for NP_001159457.1

      Status: VALIDATED

      Source sequence(s)
      AC163616, AK031934
      Consensus CDS
      CCDS50965.1
      UniProtKB/TrEMBL
      Q8BJ53
      Related
      ENSMUSP00000143638.2, ENSMUST00000195995.5
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:527 → 554
      DUF3697; Ubiquitin-associated protein 2

    4. NM_001165986.1 → NP_001159458.1  ubiquitin-associated protein 2-like isoform 5

      See identical proteins and their annotated locations for NP_001159458.1

      Status: VALIDATED

      Source sequence(s)
      AC163616, AK031934, AK079895, BB842333
      Consensus CDS
      CCDS50965.1
      UniProtKB/TrEMBL
      Q8BJ53
      Related
      ENSMUSP00000143254.2, ENSMUST00000199834.5
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:527 → 554
      DUF3697; Ubiquitin-associated protein 2

    5. NM_001165987.2 → NP_001159459.1  ubiquitin-associated protein 2-like isoform 6

      See identical proteins and their annotated locations for NP_001159459.1

      Status: VALIDATED

      Source sequence(s)
      AC163616, AK031934, BB648932
      Consensus CDS
      CCDS79959.1
      UniProtKB/TrEMBL
      A0A0H2UH17, Q8BJ53
      Related
      ENSMUSP00000088424.8, ENSMUST00000090908.11
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496 → 523
      DUF3697; Ubiquitin-associated protein 2

    6. NM_001165988.1 → NP_001159460.1  ubiquitin-associated protein 2-like isoform 6

      See identical proteins and their annotated locations for NP_001159460.1

      Status: VALIDATED

      Source sequence(s)
      AC163616, AK031934, BB842333
      Consensus CDS
      CCDS79959.1
      UniProtKB/TrEMBL
      A0A0H2UH17, Q8BJ53
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496 → 523
      DUF3697; Ubiquitin-associated protein 2

    7. NM_001357307.1 → NP_001344236.1  ubiquitin-associated protein 2-like isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC163616
      UniProtKB/TrEMBL
      Q812D5
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507 → 534
      DUF3697; Ubiquitin-associated protein 2

    8. NM_028475.3 → NP_082751.1  ubiquitin-associated protein 2-like isoform 1

      See identical proteins and their annotated locations for NP_082751.1

      Status: VALIDATED

      Source sequence(s)
      AC163616, AK016538, BB648932, BC029075, BM935680
      Consensus CDS
      CCDS38498.1
      UniProtKB/TrEMBL
      Q812D5
      Related
      ENSMUSP00000029553.10, ENSMUST00000029553.16
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:516 → 543
      DUF3697; Ubiquitin-associated protein 2

    9. NM_153489.3 → NP_705693.2  ubiquitin-associated protein 2-like isoform 2

      See identical proteins and their annotated locations for NP_705693.2

      Status: VALIDATED

      Source sequence(s)
      AC163616, BB648932
      Consensus CDS
      CCDS79958.1
      UniProtKB/TrEMBL
      A0A0G2JDV6, Q812D5
      Related
      ENSMUSP00000142524.2, ENSMUST00000198322.5
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496 → 523
      DUF3697; Ubiquitin-associated protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89906896..89959867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163363.1 → XP_036019256.1  ubiquitin-associated protein 2-like isoform X1

      UniProtKB/TrEMBL
      Q8BJ53
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:532 → 559
      DUF3697; Ubiquitin-associated protein 2

    2. XM_006502186.2 → XP_006502249.1  ubiquitin-associated protein 2-like isoform X1

      UniProtKB/TrEMBL
      Q8BJ53
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:532 → 559
      DUF3697; Ubiquitin-associated protein 2

    3. XM_011240246.3 → XP_011238548.1  ubiquitin-associated protein 2-like isoform X2

      UniProtKB/TrEMBL
      Q8BJ53
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:532 → 559
      DUF3697; Ubiquitin-associated protein 2

    4. XM_030252854.2 → XP_030108714.1  ubiquitin-associated protein 2-like isoform X3

      UniProtKB/TrEMBL
      Q8BJ53
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496 → 523
      DUF3697; Ubiquitin-associated protein 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80X50.1 GenPept UniProtKB/Swiss-Prot:Q80X50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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