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    Xkrx X-linked Kx blood group related, X-linked [ Mus musculus (house mouse) ]

    Gene ID: 331524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xkrxprovided by MGI
    Official Full Name
    X-linked Kx blood group related, X-linkedprovided by MGI
    Primary source
    MGI:MGI:3584011
    See related
    Ensembl:ENSMUSG00000031258 AllianceGenome:MGI:3584011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630026F04
    Summary
    Predicted to be located in membrane. Orthologous to human XKRX (XK related X-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 1.8), genital fat pad adult (RPKM 1.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xkrx in Genome Data Viewer
    Location:
    X E3; X 55.85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133049786..133086747, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134149037..134185497, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene cleavage stimulation factor, 3' pre-RNA subunit 2 Neighboring gene microRNA 3112 Neighboring gene predicted gene, 54083 Neighboring gene NADPH oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_47954 Neighboring gene ADP-ribosylation factor-like 13A Neighboring gene STARR-seq mESC enhancer starr_47955 Neighboring gene TRM2 tRNA methyltransferase 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    XK-related protein 2
    Names
    Kell blood group complex subunit-related, X-linked
    X Kell blood group precursor related X linked

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365115.1 → NP_001352044.1  XK-related protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AY534249, BQ174759, CJ045765, CJ046079, CJ056414
      Conserved Domains (1) summary
      pfam09815
      Location:1 → 203
      XK-related; XK-related protein

    2. NM_183319.3 → NP_899142.2  XK-related protein 2 isoform 1

      See identical proteins and their annotated locations for NP_899142.2

      Status: VALIDATED

      Source sequence(s)
      AY534249, BQ174759, CJ045765, CJ045779, CJ046079
      Consensus CDS
      CCDS30391.1
      UniProtKB/Swiss-Prot
      A2AEK6, Q5GH68
      Related
      ENSMUSP00000033611.5, ENSMUST00000033611.5
      Conserved Domains (1) summary
      pfam09815
      Location:36 → 407
      XK-related; XK-related protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133049786..133086747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161993.1 → XP_036017886.1  XK-related protein 2 isoform X3

      Conserved Domains (1) summary
      pfam09815
      Location:1 → 203
      XK-related; XK-related protein

    2. XM_006528569.5 → XP_006528632.1  XK-related protein 2 isoform X2

      Conserved Domains (1) summary
      pfam09815
      Location:17 → 291
      XK-related; XK-related protein

    3. XM_017318525.3 → XP_017174014.1  XK-related protein 2 isoform X1

      Conserved Domains (1) summary
      pfam09815
      Location:1 → 306
      XK-related; XK-related protein

    4. XM_036161992.1 → XP_036017885.1  XK-related protein 2 isoform X2

      Conserved Domains (1) summary
      pfam09815
      Location:17 → 291
      XK-related; XK-related protein

    5. XM_006528568.5 → XP_006528631.1  XK-related protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528631.1

      Conserved Domains (1) summary
      pfam09815
      Location:1 → 306
      XK-related; XK-related protein

    6. XM_006528570.5 → XP_006528633.1  XK-related protein 2 isoform X3

      Conserved Domains (1) summary
      pfam09815
      Location:1 → 203
      XK-related; XK-related protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GH68.1 GenPept UniProtKB/Swiss-Prot:Q5GH68

    Gene LinkOut

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