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    Calr3 calreticulin 3 [ Mus musculus (house mouse) ]

    Gene ID: 73316, updated on 9-Dec-2024

    Summary

    Official Symbol
    Calr3provided by MGI
    Official Full Name
    calreticulin 3provided by MGI
    Primary source
    MGI:MGI:1920566
    See related
    Ensembl:ENSMUSG00000019732 AllianceGenome:MGI:1920566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crt2; cspn; 1700031L01Rik; 6330586I20Rik
    Summary
    Enables protein folding chaperone. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum lumen and nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cerebral cortex and telencephalon. Orthologous to human CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 18.6) and heart adult (RPKM 2.7) See more
    Orthologs
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    Genomic context

    See Calr3 in Genome Data Viewer
    Location:
    8 B3.3; 8 35.08 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73178020..73197638, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72424176..72443819, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3785 Neighboring gene STARR-seq mESC enhancer starr_21854 Neighboring gene STARR-seq mESC enhancer starr_21858 Neighboring gene Kruppel-like transcription factor 2 (lung) Neighboring gene STARR-positive B cell enhancer ABC_E8247 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9731 Neighboring gene STARR-positive B cell enhancer ABC_E5020 Neighboring gene predicted gene, 46043 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene STARR-positive B cell enhancer ABC_E359 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene microRNA 7068

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calreticulin-3
    Names
    calreticulin-2
    calspeculin
    calsperin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028500.3NP_082776.2  calreticulin-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_082776.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK006582, AK046081
      Consensus CDS
      CCDS22413.1
      UniProtKB/Swiss-Prot
      G5E827, Q9D9Q6
      UniProtKB/TrEMBL
      B1Q2L7
      Related
      ENSMUSP00000019876.6, ENSMUST00000019876.12
      Conserved Domains (1) summary
      pfam00262
      Location:23315
      Calreticulin; Calreticulin family
    2. NM_029782.3NP_084058.2  calreticulin-3 isoform 2

      See identical proteins and their annotated locations for NP_084058.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and 5' coding region, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK046081
      Consensus CDS
      CCDS40388.1
      UniProtKB/TrEMBL
      Q8BL82
      Related
      ENSMUSP00000105601.2, ENSMUST00000109974.2
      Conserved Domains (1) summary
      pfam00262
      Location:25207
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      73178020..73197638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509761.5XP_006509824.1  calreticulin-3 isoform X1

      UniProtKB/TrEMBL
      B1Q2L7
      Conserved Domains (1) summary
      pfam00262
      Location:23257
      Calreticulin; Calreticulin family
    2. XM_030243800.1XP_030099660.1  calreticulin-3 isoform X2

      Conserved Domains (1) summary
      pfam00262
      Location:25149
      Calreticulin; Calreticulin family