Tut1 terminal uridylyl transferase 1, U6 snRNA-specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tut1provided by MGI
Official Full Name: terminal uridylyl transferase 1, U6 snRNA-specificprovided by MGI
Primary source: MGI:MGI:1917294
See related: Ensembl:ENSMUSG00000071645 AllianceGenome:MGI:1917294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAPD2; Rbm21; Tent1; TUTase6; star-PAP; U6-TUTase; 2700038E08Rik
Summary: Predicted to enable several functions, including RNA binding activity; enzyme-substrate adaptor activity; and nucleotidyltransferase activity. Predicted to be involved in U6 snRNA 3'-end processing and co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Predicted to be located in cytosol and nucleolus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in mitochondrion and nuclear speck. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 15.7), thymus adult (RPKM 11.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.04 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8931199..8943572)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8953832..8966210)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.
Title: USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.
TUT1 nucleotidyl transferase interacts with LARP7 protein to regulate Lin28 expression.
Title: Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237888

Tut1 (e-PCR), detects polymorphism
- UniSTS:479228

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA uridylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables RNA uridylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables poly(A) RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in U6 snRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in U6 snRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	ISO Inferred from Sequence Orthology more info
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in histone mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in snRNA processing	ISO Inferred from Sequence Orthology more info
involved_in snRNA processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: speckle targeted PIP5K1A-regulated poly(A) polymerase

Names: RNA binding motif protein 21

NP_932110.1

EC 2.7.7.19

EC 2.7.7.52

XP_030106934.1

EC 2.7.7.19

EC 2.7.7.52

XP_036017576.1

EC 2.7.7.19

EC 2.7.7.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_197993.4 → NP_932110.1 speckle targeted PIP5K1A-regulated poly(A) polymerase

See identical proteins and their annotated locations for NP_932110.1

Status: VALIDATED

Source sequence(s)

AC130819

Consensus CDS

CCDS29562.1

UniProtKB/Swiss-Prot

Q3UUH3, Q8R3F9

Related

ENSMUSP00000093958.6, ENSMUST00000096239.7

Conserved Domains (4) summary

cd05402
Location:179 → 403

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

smart00451
Location:14 → 47

ZnF_U1; U1-like zinc finger

COG0724
Location:56 → 140

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12279
Location:54 → 127

RRM_TUT1; RNA recognition motif in speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

8931199..8943572

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251074.2 → XP_030106934.1 speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X1

Conserved Domains (3) summary

cd05402
Location:81 → 305

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

COG5260
Location:262 → 355

TRF4; DNA polymerase sigma [Replication, recombination and repair]

cl17169
Location:1 → 29

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036161683.1 → XP_036017576.1 speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X2

Conserved Domains (2) summary

pfam03828
Location:89 → 148

PAP_assoc; Cid1 family poly A polymerase

pfam19088
Location:4 → 50

TUTase; TUTase nucleotidyltransferase domain