Sstr3 somatostatin receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sstr3provided by MGI
Official Full Name: somatostatin receptor 3provided by MGI
Primary source: MGI:MGI:98329
See related: Ensembl:ENSMUSG00000044933 AllianceGenome:MGI:98329
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sst3; Smstr3; Smstr-3
Summary: Enables signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Located in ciliary membrane; neuron projection; and non-motile cilium. Is expressed in several structures, including central nervous system; cochlea; gallbladder; genitourinary system; and gut. Orthologous to human SSTR3 (somatostatin receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 2.7), cortex adult (RPKM 2.1) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78421214..78433565, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (78537014..78549365, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
Title: Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
Title: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
Title: Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
results implicate beta-arrestin in the modulation of Sstr3 ciliary localization and further suggest a role for beta-arrestin in the mediation of Sstr3 ciliary signaling.
Title: Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization.
The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
Title: Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
Both Sstr3 (and SStr2) receptors are required for the anticonvulsant effects mediated by cortistatin-14.
Title: Cortistatin-14 mediates its anticonvulsant effects via sst2 and sst3 but not ghrelin receptors.
SSTR3 immunoreactivity increases in ApoD(-/-) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.
Mchr1 and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers.
Title: Heteromerization of ciliary G protein-coupled receptors in the mouse brain.
this novel finding that Rab21 regulates SSTR3 trafficking suggests that Rab21 may play a role in trafficking of other GPCRs.
Title: Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3.
somatostatin receptor 3 expression was restricted to the plasma membrane of cilia in insulin- and growth hormone-secreting cells of the mouse, differing from previously reported immunohistochemical localization in cell bodies
Title: Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491278

Smstr3 (e-PCR), detects polymorphism
- UniSTS:144457

Smstr3 (e-PCR), detects polymorphism
- UniSTS:144458

Smstr3 (e-PCR), detects polymorphism
- UniSTS:144459

Smstr3 (e-PCR), detects polymorphism
- UniSTS:144460

Smstr3 (e-PCR), detects polymorphism
- UniSTS:144461

M91000 (e-PCR)
- UniSTS:186318

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables somatostatin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IEA Inferred from Electronic Annotation more info
involved_in somatostatin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: somatostatin receptor type 3

Names: SS-3-R; SS3-R; SS3R; SSR-28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356961.1 → NP_001343890.1 somatostatin receptor type 3

Status: VALIDATED

Source sequence(s)

AL590144

Consensus CDS

CCDS27617.1

UniProtKB/Swiss-Prot

P30935, Q0VB04, Q3UVV5

Conserved Domains (2) summary

cd14964
Location:48 → 72

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 333

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001411768.1 → NP_001398697.1 somatostatin receptor type 3

Status: VALIDATED

Source sequence(s)

AL590144

UniProtKB/Swiss-Prot

P30935, Q0VB04, Q3UVV5
NM_009218.3 → NP_033244.2 somatostatin receptor type 3

See identical proteins and their annotated locations for NP_033244.2

Status: VALIDATED

Source sequence(s)

AL590144

Consensus CDS

CCDS27617.1

UniProtKB/Swiss-Prot

P30935, Q0VB04, Q3UVV5

Related

ENSMUSP00000058040.3, ENSMUST00000053239.4

Conserved Domains (2) summary

cd14964
Location:48 → 72

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 333

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

78421214..78433565 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245531.2 → XP_011243833.1 somatostatin receptor type 3 isoform X1

See identical proteins and their annotated locations for XP_011243833.1

UniProtKB/Swiss-Prot

P30935, Q0VB04, Q3UVV5

Conserved Domains (2) summary

cd14964
Location:48 → 72

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:46 → 333

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily