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    Rnf32 ring finger protein 32 [ Mus musculus (house mouse) ]

    Gene ID: 56874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf32provided by MGI
    Official Full Name
    ring finger protein 32provided by MGI
    Primary source
    MGI:MGI:1861747
    See related
    Ensembl:ENSMUSG00000029130 AllianceGenome:MGI:1861747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmbr2; 1700009J01Rik; 2700025B22Rik; 4930542N22Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in several cellular components, including aggresome; endosome; and nuclear body. Is expressed in several structures, including alimentary system; genitourinary system; limb; olfactory epithelium; and trunk. Orthologous to human RNF32 (ring finger protein 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 24.5), CNS E18 (RPKM 2.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf32 in Genome Data Viewer
    Location:
    5 B1; 5 14.78 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (29397743..29432633)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (29192745..29227635)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35688 Neighboring gene Shh brain enhancer 3 Neighboring gene STARR-seq mESC enhancer starr_12726 Neighboring gene predicted gene, 35881 Neighboring gene STARR-seq mESC enhancer starr_12727 Neighboring gene mammal reptile conserved sequence 1 Neighboring gene STARR-seq mESC enhancer starr_12728 Neighboring gene mammal fish conserved sequence 3 Neighboring gene STARR-seq mESC enhancer starr_12729 Neighboring gene mammal fish conserved sequence 4 Neighboring gene predicted gene 7420 Neighboring gene mammal amphibian conserved sequence 1 Neighboring gene limb region 1 Neighboring gene STARR-seq mESC enhancer starr_12732 Neighboring gene STARR-seq mESC enhancer starr_12733 Neighboring gene STARR-seq mESC enhancer starr_12734 Neighboring gene zone of polarising activity regulatory sequence 1 Neighboring gene STARR-positive B cell enhancer ABC_E9634 Neighboring gene predicted gene, 36086

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization. Sagai T, et al. Proc Natl Acad Sci U S A, 2019 Nov 19. PMID 31685615, Free PMC Article
    2. A double RING-H2 domain in RNF32, a gene expressed during sperm formation. van Baren MJ, et al. Biochem Biophys Res Commun, 2002 Mar 22. PMID 11890671
    3. The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances. Symmons O, et al. Dev Cell, 2016 Dec 5. PMID 27867070, Free PMC Article
    4. Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Amano T, et al. Dev Cell, 2009 Jan. PMID 19097946
    5. Mapping the Shh long-range regulatory domain. Anderson E, et al. Development, 2014 Oct. PMID 25252942, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC107158

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 32
    Names
    limb region protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289757.1 → NP_001276686.1  RING finger protein 32

      See identical proteins and their annotated locations for NP_001276686.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK012288, AV284199, BC089493, BY293373
      Consensus CDS
      CCDS39041.1
      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Related
      ENSMUSP00000001247.6, ENSMUST00000001247.12
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    2. NM_021470.6 → NP_067445.3  RING finger protein 32

      See identical proteins and their annotated locations for NP_067445.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK005795, AK012288, AV284199, BC089493, BY293373
      Consensus CDS
      CCDS39041.1
      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Related
      ENSMUSP00000124657.2, ENSMUST00000160246.8
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    RNA

    1. NR_110371.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK012288, AV284199, BY293373
      Related
      ENSMUST00000160383.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      29397743..29432633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535775.4 → XP_006535838.1  RING finger protein 32 isoform X1

      See identical proteins and their annotated locations for XP_006535838.1

      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    2. XM_030254724.1 → XP_030110584.1  RING finger protein 32 isoform X2

      UniProtKB/TrEMBL
      F6URG7
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:238 → 305
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    3. XM_006535781.4 → XP_006535844.1  RING finger protein 32 isoform X1

      See identical proteins and their annotated locations for XP_006535844.1

      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    4. XM_036165367.1 → XP_036021260.1  RING finger protein 32 isoform X4

      Conserved Domains (2) summary
      cd16678
      Location:128 → 195
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:24 → 43
      IQ; IQ calmodulin-binding motif

    5. XM_006535780.3 → XP_006535843.1  RING finger protein 32 isoform X1

      See identical proteins and their annotated locations for XP_006535843.1

      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    6. XM_036165368.1 → XP_036021261.1  RING finger protein 32 isoform X4

      Conserved Domains (2) summary
      cd16678
      Location:128 → 195
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:24 → 43
      IQ; IQ calmodulin-binding motif

    7. XM_036165363.1 → XP_036021256.1  RING finger protein 32 isoform X2

      UniProtKB/TrEMBL
      F6URG7
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:238 → 305
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    8. XM_036165366.1 → XP_036021259.1  RING finger protein 32 isoform X4

      Conserved Domains (2) summary
      cd16678
      Location:128 → 195
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:24 → 43
      IQ; IQ calmodulin-binding motif

    9. XM_036165365.1 → XP_036021258.1  RING finger protein 32 isoform X3

      UniProtKB/TrEMBL
      F6URG7
      Conserved Domains (3) summary
      cd16677
      Location:54 → 97
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:220 → 287
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:116 → 135
      IQ; IQ calmodulin-binding motif

    10. XM_006535778.3 → XP_006535841.1  RING finger protein 32 isoform X1

      See identical proteins and their annotated locations for XP_006535841.1

      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    11. XM_006535782.3 → XP_006535845.1  RING finger protein 32 isoform X2

      UniProtKB/TrEMBL
      F6URG7
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:238 → 305
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    12. XM_017321036.1 → XP_017176525.1  RING finger protein 32 isoform X4

      Conserved Domains (2) summary
      cd16678
      Location:128 → 195
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:24 → 43
      IQ; IQ calmodulin-binding motif

    13. XM_030254726.1 → XP_030110586.1  RING finger protein 32 isoform X4

      Conserved Domains (2) summary
      cd16678
      Location:128 → 195
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:24 → 43
      IQ; IQ calmodulin-binding motif

    14. XM_030254725.1 → XP_030110585.1  RING finger protein 32 isoform X3

      UniProtKB/TrEMBL
      F6URG7
      Conserved Domains (3) summary
      cd16677
      Location:54 → 97
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:220 → 287
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:116 → 135
      IQ; IQ calmodulin-binding motif

    15. XM_006535777.3 → XP_006535840.1  RING finger protein 32 isoform X1

      See identical proteins and their annotated locations for XP_006535840.1

      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    16. XM_036165364.1 → XP_036021257.1  RING finger protein 32 isoform X2

      UniProtKB/TrEMBL
      F6URG7
      Related
      ENSMUSP00000123952.2, ENSMUST00000162975.2
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:238 → 305
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    17. XM_006535779.3 → XP_006535842.1  RING finger protein 32 isoform X1

      See identical proteins and their annotated locations for XP_006535842.1

      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif

    18. XM_030254727.1 → XP_030110587.1  RING finger protein 32 isoform X4

      Conserved Domains (2) summary
      cd16678
      Location:128 → 195
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:24 → 43
      IQ; IQ calmodulin-binding motif

    19. XM_030254728.1 → XP_030110588.1  RING finger protein 32 isoform X4

      Conserved Domains (2) summary
      cd16678
      Location:128 → 195
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:24 → 43
      IQ; IQ calmodulin-binding motif

    20. XM_006535776.5 → XP_006535839.1  RING finger protein 32 isoform X1

      See identical proteins and their annotated locations for XP_006535839.1

      UniProtKB/Swiss-Prot
      Q9D9X0, Q9DAJ3, Q9JIT1
      Conserved Domains (3) summary
      cd16677
      Location:128 → 171
      RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      cd16678
      Location:294 → 361
      RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
      pfam00612
      Location:190 → 209
      IQ; IQ calmodulin-binding motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIT1.1 GenPept UniProtKB/Swiss-Prot:Q9JIT1

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