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    Msl2 MSL complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 77853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msl2provided by MGI
    Official Full Name
    MSL complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1925103
    See related
    Ensembl:ENSMUSG00000066415 AllianceGenome:MGI:1925103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msl2l1; Rnf184; E130103E02Rik
    Summary
    Enables histone H2B ubiquitin ligase activity and promoter-enhancer loop anchoring activity. Involved in epigenetic regulation of gene expression and positive regulation of DNA-templated transcription. Part of MSL complex. Is active in nucleus. Is expressed in embryo. Orthologous to human MSL2 (MSL complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.4), spleen adult (RPKM 9.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Msl2 in Genome Data Viewer
    Location:
    9 E4; 9 53.17 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100956107..100981999)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (101074054..101104800)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:100965416-100965626 Neighboring gene STARR-seq mESC enhancer starr_25047 Neighboring gene brain expressed X-linked 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5097 Neighboring gene predicted gene, 46140 Neighboring gene protein phosphatase 2, regulatory subunit B'', alpha Neighboring gene predicted gene, 24338 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MSL2 ensures biallelic gene expression in mammals. Sun Y, et al. Nature, 2023 Dec. PMID 38030723, Free PMC Article
    2. Msl2 is a novel component of the vertebrate DNA damage response. Lai Z, et al. PLoS One, 2013. PMID 23874665, Free PMC Article
    3. MSL2 promotes Mdm2-independent cytoplasmic localization of p53. Kruse JP, et al. J Biol Chem, 2009 Jan 30. PMID 19033443, Free PMC Article
    4. Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Wolstenholme JT, et al. Genes Brain Behav, 2013 Mar. PMID 23210685, Free PMC Article
    5. Evolution of chromatin-remodeling complexes: comparative genomics reveals the ancient origin of "novel" compensasome genes. Marín I. J Mol Evol, 2003 May. PMID 12698291

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MSL2 ensures biallelic gene expression in mammals.
      Title: MSL2 ensures biallelic gene expression in mammals.
    2. Msl2 is a novel component of the vertebrate DNA damage response.
      Title: Msl2 is a novel component of the vertebrate DNA damage response.
    3. the MSL2-mediated effect on p53 is Mdm2-independent. Thus, our study identifies an important ubiquitin-ligase for modulating p53 subcellular localization
      Title: MSL2 promotes Mdm2-independent cytoplasmic localization of p53.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2B ubiquitin ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H2B ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2B ubiquitin ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-enhancer loop anchoring activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MSL complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MSL complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MSL2
    Names
    E3 ubiquitin-protein transferase MSL2
    MSL2-like 1
    male-specific lethal 2 homolog
    male-specific lethal 2-like 1
    male-specific lethal-2 homolog 1
    ring finger protein 184
    NP_001093921.1
    NP_001366273.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100451.2 → NP_001093921.1  E3 ubiquitin-protein ligase MSL2 isoform 1

      See identical proteins and their annotated locations for NP_001093921.1

      Status: VALIDATED

      Source sequence(s)
      AK035934, BC070432, BC100371, BE986573
      Consensus CDS
      CCDS85717.1
      UniProtKB/Swiss-Prot
      Q497U7, Q69ZF8, Q8CBI7
      Related
      ENSMUSP00000082270.4, ENSMUST00000085177.5
      Conserved Domains (2) summary
      cd13122
      Location:456 → 505
      MSL2_CXC; DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins
      pfam16685
      Location:42 → 111
      zf-RING_10; zinc RING finger of MSL2

    2. NM_001379344.1 → NP_001366273.1  E3 ubiquitin-protein ligase MSL2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC242670, AC242673
      Conserved Domains (3) summary
      TIGR03551
      Location:170 → 212
      F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit
      pfam16682
      Location:381 → 435
      MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2
      cl17238
      Location:1 → 37
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      100956107..100981999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZF8.2 GenPept UniProtKB/Swiss-Prot:Q69ZF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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