Spdl1 spindle apparatus coiled-coil protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spdl1provided by MGI
Official Full Name: spindle apparatus coiled-coil protein 1provided by MGI
Primary source: MGI:MGI:1917635
See related: Ensembl:ENSMUSG00000069910 AllianceGenome:MGI:1917635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccdc99; 1700018I02Rik; 2600001J17Rik; 2810049B11Rik
Summary: Predicted to enable enzyme binding activity and kinetochore binding activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase chromosome alignment; and protein localization to kinetochore. Predicted to be located in nucleus. Predicted to be part of outer kinetochore. Predicted to be active in spindle pole. Is expressed in several structures, including brain; gut; liver lobe; maturing glomerular tuft; and tooth. Orthologous to human SPDL1 (spindle apparatus coiled-coil protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 8.5), liver E14 (RPKM 7.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 19.9 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (34700012..34724492, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (34809185..34833665, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spdl1 expression is significantly down-regulated in Mrtfb knockout mouse intestine.
Title: MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.
Overexpression of mSpindly failed to enhance inactivation of SAC and acceleration of the meiotic process.
Title: Localization and function of mSpindly during mouse oocyte meiotic maturation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125878 (e-PCR)
- UniSTS:162610

AA409762 (e-PCR)
- UniSTS:160082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables kinetochore binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinetochore binding	ISO Inferred from Sequence Orthology more info
enables kinetochore binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of outer kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info
part_of outer kinetochore	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein Spindly

Names: coiled-coil domain containing 99; coiled-coil domain-containing protein 99; spindle apparatus coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027411.2 → NP_081687.2 protein Spindly

See identical proteins and their annotated locations for NP_081687.2

Status: VALIDATED

Source sequence(s)

AK139553, AK160143, BY712013, DV663229

Consensus CDS

CCDS24541.1

UniProtKB/Swiss-Prot

Q5DY45, Q923A2

Related

ENSMUSP00000090882.3, ENSMUST00000093191.3

Conserved Domains (1) summary

COG1196
Location:1 → 344

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

34700012..34724492 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534169.3 → XP_006534232.1 protein Spindly isoform X1

See identical proteins and their annotated locations for XP_006534232.1

UniProtKB/Swiss-Prot

Q5DY45, Q923A2

Conserved Domains (1) summary

COG1196
Location:1 → 344

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_036156979.1 → XP_036012872.1 protein Spindly isoform X3

Conserved Domains (1) summary

TIGR02168
Location:2 → 281

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_011249245.3 → XP_011247547.1 protein Spindly isoform X2

Conserved Domains (1) summary

COG1196
Location:18 → 283

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]