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    Cend1 cell cycle exit and neuronal differentiation 1 [ Mus musculus (house mouse) ]

    Gene ID: 57754, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cend1provided by MGI
    Official Full Name
    cell cycle exit and neuronal differentiation 1provided by MGI
    Primary source
    MGI:MGI:1929898
    See related
    Ensembl:ENSMUSG00000060240 AllianceGenome:MGI:1929898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BM88; 1500001H12Rik
    Summary
    Involved in neuron differentiation. Acts upstream of or within adult walking behavior; hindbrain development; and negative regulation of cerebellar granule cell precursor proliferation. Predicted to be located in membrane. Predicted to colocalize with mitochondrion and vesicle. Is expressed in central nervous system; peripheral nervous system ganglion; sensory organ; and urethra. Orthologous to human CEND1 (cell cycle exit and neuronal differentiation 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 92.4), cortex adult (RPKM 51.6) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cend1 in Genome Data Viewer
    Location:
    7 F5; 7 86.77 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141006359..141009475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141426446..141429562, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene glutamine amidotransferase like class 1 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3761 Neighboring gene solute carrier family 25 (mitochondrial carrier, glutamate), member 22 Neighboring gene STARR-positive B cell enhancer ABC_E4986 Neighboring gene p53 induced death domain protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1097

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cell cycle exit and neuronal differentiation protein 1
    Names
    BM88 antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360485.1NP_001347414.1  cell cycle exit and neuronal differentiation protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC158224, AC163434
      Consensus CDS
      CCDS22012.1
      UniProtKB/Swiss-Prot
      Q9DBA0, Q9JKC6
      Related
      ENSMUSP00000123334.2, ENSMUST00000137488.2
      Conserved Domains (1) summary
      pfam15677
      Location:1149
      CEND1; Cell cycle exit and neuronal differentiation protein 1
    2. NM_021316.5NP_067291.1  cell cycle exit and neuronal differentiation protein 1

      See identical proteins and their annotated locations for NP_067291.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC158224, AC163434, AK079045
      Consensus CDS
      CCDS22012.1
      UniProtKB/Swiss-Prot
      Q9DBA0, Q9JKC6
      Related
      ENSMUSP00000118591.2, ENSMUST00000124444.2
      Conserved Domains (1) summary
      pfam15677
      Location:1149
      CEND1; Cell cycle exit and neuronal differentiation protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141006359..141009475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)