Ggps1 geranylgeranyl diphosphate synthase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ggps1provided by MGI
Official Full Name: geranylgeranyl diphosphate synthase 1provided by MGI
Primary source: MGI:MGI:1341724
See related: Ensembl:ENSMUSG00000021302 AllianceGenome:MGI:1341724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810026C22Rik; 9530089B04Rik
Summary: Enables geranyltranstransferase activity. Predicted to be involved in isoprenoid biosynthetic process. Predicted to be located in several cellular components, including Z disc; nucleoplasm; and perinuclear region of cytoplasm. Is expressed in aorta; brain; heart; liver; and lung. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 5.4), CNS E18 (RPKM 5.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 5.29 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (14224375..14238319, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (14049790..14063566, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease.
Title: Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease.
CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway.
Title: CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway.
Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
Title: Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo.
Title: Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo.
Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction.
Title: Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction.
Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.
Title: Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.
The expression level of geranylgeranyl diphosphate synthase (Ggpps), is lower in Non-obstructive azoospermia (NOA) patients than that in obstructive azoospermia (OA) patients. After Ggpps deletion specifically in Sertoli cells (SCs), the mice are infertile and the phenotype of the SC-Ggpps(-/-) mice is similar to the NOA patients, where the blood-testis barrier and the SC-germ cells adhesions are severely destroyed.
Title: The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis.
The GGPPS deficiency activated lung fibroblast by facilitating transforming growth factor beta1 while antagonizing bone morphogenetic protein 4 signaling. The GGPPS provides protection against pulmonary fibrosis and that the restoration of protein geranylgeranylation may benefit statin-induced lung injury.
Title: Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-β1/BMP-4 signaling.
Geranylgeranyl pyrophosphate synthase mediated protein geranylgeranylation plays an indispensable role in the ventricular chamber maturation and acts as a stage-specific signal to regulate the establishment of cardiac cytoarchitecture during mid-gestation.
Title: Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart.
Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation
Title: Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

D19344 (e-PCR)
- UniSTS:124807

Ggps1 (e-PCR), detects polymorphism
- UniSTS:228513

AI843169 (e-PCR)
- UniSTS:165858

Ggps1 (e-PCR), detects polymorphism
- UniSTS:546789

NoName (e-PCR)
- UniSTS:237306

RH126630 (e-PCR)
- UniSTS:208891

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dimethylallyltranstransferase activity	IEA Inferred from Electronic Annotation more info
enables farnesyltranstransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables farnesyltranstransferase activity	ISO Inferred from Sequence Orthology more info
enables farnesyltranstransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables geranyltranstransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in farnesyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in geranyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in geranylgeranyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoprenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoprenoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: geranylgeranyl pyrophosphate synthase

Names: (2E,6E)-farnesyl diphosphate synthase; GGPP synthase; GGPP synthetase; GGPPSase; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyltranstransferase; geranylgeranyl pyrophosphate synthetase; geranyltranstransferase

NP_001318048.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

NP_001318105.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

NP_001318106.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

NP_001318107.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

NP_001318109.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

NP_034412.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_006516612.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_011242583.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_017170874.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_017170876.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_017170877.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_030103013.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_030103015.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_036013742.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_036013743.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_036013744.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_036013745.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

XP_036013746.1

EC 2.5.1.1

EC 2.5.1.10

EC 2.5.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331119.1 → NP_001318048.1 geranylgeranyl pyrophosphate synthase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AK011980, BC069913, BY273432, CT025604

Consensus CDS

CCDS26248.1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase
NM_001331176.1 → NP_001318105.1 geranylgeranyl pyrophosphate synthase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AK011980, BC069913, BF019769, BY273432, CT025604, CX242436

Consensus CDS

CCDS26248.1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase
NM_001331177.1 → NP_001318106.1 geranylgeranyl pyrophosphate synthase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AK011980, BC069913, BY273432, CT025604, CX242436

Consensus CDS

CCDS26248.1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase
NM_001331178.1 → NP_001318107.1 geranylgeranyl pyrophosphate synthase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

AK011980, BC069913, BF019769, BY273432, CT025604

Consensus CDS

CCDS26248.1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase
NM_001331180.1 → NP_001318109.1 geranylgeranyl pyrophosphate synthase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC069913, BY273432, CD352882, CT025604

UniProtKB/Swiss-Prot

Q9WTN0

Conserved Domains (1) summary

pfam00348
Location:1 → 197

polyprenyl_synt; Polyprenyl synthetase
NM_010282.3 → NP_034412.1 geranylgeranyl pyrophosphate synthase isoform 1

See identical proteins and their annotated locations for NP_034412.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).

Source sequence(s)

BC069913, BY273432, CT025604

Consensus CDS

CCDS26248.1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Related

ENSMUSP00000126603.2, ENSMUST00000170957.3

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase

RNA

NR_138552.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK011980, BC069913, BY273432, CT025604
NR_138553.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks an alternate internal exon and uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK011980, BC069913, BY273432, CT025604
NR_138555.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks two alternate internal exons and uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK011980, BY273432, CN537259, CT025604

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

14224375..14238319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315387.3 → XP_017170876.1 geranylgeranyl pyrophosphate synthase isoform X3

UniProtKB/TrEMBL

Q9CZZ6

Related

ENSMUSP00000152789.2, ENSMUST00000222747.2

Conserved Domains (1) summary

pfam00348
Location:9 → 221

polyprenyl_synt; Polyprenyl synthetase
XM_036157853.1 → XP_036013746.1 geranylgeranyl pyrophosphate synthase isoform X3

UniProtKB/TrEMBL

Q9CZZ6

Conserved Domains (1) summary

pfam00348
Location:9 → 221

polyprenyl_synt; Polyprenyl synthetase
XM_017315388.3 → XP_017170877.1 geranylgeranyl pyrophosphate synthase isoform X3

UniProtKB/TrEMBL

Q9CZZ6

Conserved Domains (1) summary

pfam00348
Location:9 → 221

polyprenyl_synt; Polyprenyl synthetase
XM_011244281.4 → XP_011242583.1 geranylgeranyl pyrophosphate synthase isoform X3

See identical proteins and their annotated locations for XP_011242583.1

UniProtKB/TrEMBL

Q9CZZ6

Conserved Domains (1) summary

pfam00348
Location:9 → 221

polyprenyl_synt; Polyprenyl synthetase
XM_006516549.5 → XP_006516612.1 geranylgeranyl pyrophosphate synthase isoform X1

See identical proteins and their annotated locations for XP_006516612.1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase
XM_030247155.2 → XP_030103015.1 geranylgeranyl pyrophosphate synthase isoform X3

UniProtKB/TrEMBL

Q9CZZ6

Related

ENSMUSP00000152428.2, ENSMUST00000222164.2

Conserved Domains (1) summary

pfam00348
Location:9 → 221

polyprenyl_synt; Polyprenyl synthetase
XM_036157852.1 → XP_036013745.1 geranylgeranyl pyrophosphate synthase isoform X3

UniProtKB/TrEMBL

Q9CZZ6

Conserved Domains (1) summary

pfam00348
Location:9 → 221

polyprenyl_synt; Polyprenyl synthetase
XM_017315385.3 → XP_017170874.1 geranylgeranyl pyrophosphate synthase isoform X1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase
XM_036157849.1 → XP_036013742.1 geranylgeranyl pyrophosphate synthase isoform X1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase
XM_036157850.1 → XP_036013743.1 geranylgeranyl pyrophosphate synthase isoform X1

UniProtKB/Swiss-Prot

Q9WTN0

UniProtKB/TrEMBL

Q3V0T8

Conserved Domains (1) summary

pfam00348
Location:9 → 251

polyprenyl_synt; Polyprenyl synthetase
XM_036157851.1 → XP_036013744.1 geranylgeranyl pyrophosphate synthase isoform X2

Conserved Domains (1) summary

pfam00348
Location:1 → 197

polyprenyl_synt; Polyprenyl synthetase
XM_030247153.2 → XP_030103013.1 geranylgeranyl pyrophosphate synthase isoform X2

Conserved Domains (1) summary

pfam00348
Location:1 → 197

polyprenyl_synt; Polyprenyl synthetase