Adgrf1 adhesion G protein-coupled receptor F1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrf1provided by MGI
Official Full Name: adhesion G protein-coupled receptor F1provided by MGI
Primary source: MGI:MGI:1924846
See related: Ensembl:ENSMUSG00000041293 AllianceGenome:MGI:1924846
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr110; KPG_009; 5031409J19Rik
Summary: Enables G protein-coupled receptor activity. Acts upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Located in plasma membrane. Is expressed in adrenal gland; liver; and metanephros. Orthologous to human ADGRF1 (adhesion G protein-coupled receptor F1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 3.1), liver adult (RPKM 1.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 19.71 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (43581174..43636767)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (43270283..43325876)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
Title: Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1).
Title: Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1).
Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation.
Title: Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation.
Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.
Title: Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.
GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice.
Title: GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice.
Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.
Title: Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.
Study demonstrated orphan G-protein coupled receptor 110 (GPR110, ADGRF1) as the synaptamide receptor, mediating synaptamide-induced bioactivity in a cAMP-dependent manner.
Title: Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

Gpr110 (e-PCR), detects polymorphism
- UniSTS:547983

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in energy reserve metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of CREB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adhesion G-protein coupled receptor F1

Names: G protein coupled receptor Gpr110; G-protein coupled receptor 110; internal gene name of KIRIN laboratory:M5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133776.3 → NP_598537.2 adhesion G-protein coupled receptor F1 precursor

See identical proteins and their annotated locations for NP_598537.2

Status: VALIDATED

Source sequence(s)

CT025700

Consensus CDS

CCDS28795.1

UniProtKB/Swiss-Prot

B0V2Q5, Q8BMV8, Q8VEC3

Related

ENSMUSP00000049380.6, ENSMUST00000047399.6

Conserved Domains (4) summary

smart00303
Location:530 → 571

GPS; G-protein-coupled receptor proteolytic site domain

cd14964
Location:584 → 607

7tm_GPCRs; TM helix 1 [structural motif]

pfam01390
Location:153 → 240

SEA; SEA domain

cl28897
Location:584 → 847

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

43581174..43636767

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525120.4 → XP_006525183.1 adhesion G-protein coupled receptor F1 isoform X1

Conserved Domains (4) summary

smart00303
Location:549 → 590

GPS; G-protein-coupled receptor proteolytic site domain

cd14964
Location:603 → 626

7tm_GPCRs; TM helix 1 [structural motif]

pfam01390
Location:172 → 258

SEA; SEA domain

cl28897
Location:603 → 866

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006525121.4 → XP_006525184.1 adhesion G-protein coupled receptor F1 isoform X2

Conserved Domains (4) summary

smart00303
Location:548 → 589

GPS; G-protein-coupled receptor proteolytic site domain

cd14964
Location:602 → 625

7tm_GPCRs; TM helix 1 [structural motif]

pfam01390
Location:171 → 257

SEA; SEA domain

cl28897
Location:602 → 865

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily