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    Ccl22 C-C motif chemokine ligand 22 [ Mus musculus (house mouse) ]

    Gene ID: 20299, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccl22provided by MGI
    Official Full Name
    C-C motif chemokine ligand 22provided by MGI
    Primary source
    MGI:MGI:1306779
    See related
    Ensembl:ENSMUSG00000031779 AllianceGenome:MGI:1306779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDC; DCBCK; ABCD-1; Scya22
    Summary
    Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; chemokine-mediated signaling pathway; and eosinophil chemotaxis. Located in extracellular space. Is expressed in dermis; epidermis; inguinal lymph node; thymus; and thymus primordium. Orthologous to human CCL22 (C-C motif chemokine ligand 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 44.5), mammary gland adult (RPKM 25.2) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ccl22 in Genome Data Viewer
    Location:
    8 C5; 8 46.75 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95472312..95478016)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94745684..94751388)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53412 Neighboring gene STARR-positive B cell enhancer ABC_E707 Neighboring gene STARR-seq mESC enhancer starr_22362 Neighboring gene nuclear encoded tRNA leucine 5 (anticodon CAG) Neighboring gene nuclear encoded tRNA leucine 4 (anticodon CAG) Neighboring gene guanine nucleotide binding protein (G protein), beta 1, pseudogene 3 Neighboring gene C-X3-C motif chemokine ligand 1 Neighboring gene predicted gene, 51543

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (3) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    C-C motif chemokine 22
    Names
    CC chemokine ABCD-1
    SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED)
    activated B and dendritic cell-derived
    chemokine (C-C motif) ligand 22
    dendritic cell and B cell derived chemokine
    small inducible cytokine subfamily A, member 22
    small inducible cytokine subfamily A22
    small-inducible cytokine A22

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009137.2NP_033163.1  C-C motif chemokine 22 precursor

      See identical proteins and their annotated locations for NP_033163.1

      Status: VALIDATED

      Source sequence(s)
      AK155764, BF661256, BY198556
      Consensus CDS
      CCDS40441.1
      UniProtKB/Swiss-Prot
      O88430
      UniProtKB/TrEMBL
      Q546S6, Q9QZU2
      Related
      ENSMUSP00000034231.4, ENSMUST00000034231.4
      Conserved Domains (1) summary
      cd00272
      Location:3692
      Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95472312..95478016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)