Pgs1 phosphatidylglycerophosphate synthase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgs1provided by MGI
Official Full Name: phosphatidylglycerophosphate synthase 1provided by MGI
Primary source: MGI:MGI:1921701
See related: Ensembl:ENSMUSG00000017715 AllianceGenome:MGI:1921701
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SAF; 2610019F11Rik; 4933424M23Rik
Summary: Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process and diacylglycerol metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and skin. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 69.2), lung adult (RPKM 38.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 82.96 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (117876505..117914837)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (117986297..118024011)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in diacylglycerol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Names: PGP synthase 1; silencer-associated factor

NP_598518.1

EC 2.7.8.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133757.2 → NP_598518.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

See identical proteins and their annotated locations for NP_598518.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer protein-coding transcript.

Source sequence(s)

AK049359

Consensus CDS

CCDS25698.1

UniProtKB/Swiss-Prot

Q8BHF7, Q8QZT9, Q8R4R7

UniProtKB/TrEMBL

B9EKS7, F8WI04

Related

ENSMUSP00000121973.2, ENSMUST00000132676.8

Conserved Domains (2) summary

cd09135
Location:93 → 266

PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases

cd09137
Location:346 → 505

PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases

RNA

NR_151726.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK046174, AK049359, AK163967, AW045732

Related

ENSMUST00000017859.10