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Ptk2b PTK2 protein tyrosine kinase 2 beta [ Mus musculus (house mouse) ]

Gene ID: 19229, updated on 10-Dec-2024

Summary

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Official Symbol: Ptk2bprovided by MGI
Official Full Name: PTK2 protein tyrosine kinase 2 betaprovided by MGI
Primary source: MGI:MGI:104908
See related: Ensembl:ENSMUSG00000059456 AllianceGenome:MGI:104908
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAKB; FAK2; PYK2; CADTK; FADK2; Raftk; CAKbeta; E430023O05Rik
Summary: Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of cell migration; and regulation of organelle organization. Acts upstream of with a positive effect on positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within cellular response to fluid shear stress and protein phosphorylation. Located in nucleus and perinuclear region of cytoplasm. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and liver. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in frontal lobe adult (RPKM 53.4), cortex adult (RPKM 51.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

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See Ptk2b in Genome Data Viewer

Location:: 14 D1; 14 34.36 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (66390706..66518549, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (66153257..66281100, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3beta-Srebp2 axis.
Title: Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis.
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia.
Title: Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia.
PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas.
Title: PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas.
[Time dependent expression profiling of PTK2B and its relationship with Abeta, Tau and LRP-1 in hippocampus and blood of APPswe/PS1dE9 double-transgenic mouse].
Title: [Time dependent expression profiling of PTK2B and its relationship with Aβ, Tau and LRP-1 in hippocampus and blood of APPswe/PS1dE9 double-transgenic mouse].
Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis.
Title: Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis.
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.
Title: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.
Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons.
Title: Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons.
Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk.
Title: Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk.
Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner.
Title: Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner.
Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells.
Title: Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (16) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptk2b (e-PCR), detects polymorphism
- UniSTS:546515

Ptk2b (e-PCR), detects polymorphism
- UniSTS:546516

BE120275 (e-PCR)
- UniSTS:247285

D14Mit123 (e-PCR), detects polymorphism
- UniSTS:127228

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase binding	IEA Inferred from Electronic Annotation more info
enables 3-phosphoinositide-dependent protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables calcium/calmodulin-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor regulator activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in activation of Janus kinase activity	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular defense response	ISO Inferred from Sequence Orthology more info
involved_in cellular defense response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to fluid shear stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cortical cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in marginal zone B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to cation stress	IEA Inferred from Electronic Annotation more info
involved_in response to cation stress	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to immobilization stress	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal complex assembly	IEA Inferred from Electronic Annotation more info
involved_in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein-tyrosine kinase 2-beta

Names: CAK-beta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; focal adhesion kinase 2; proline-rich tyrosine kinase 2; related adhesion focal tyrosine kinase

NP_001155837.1

EC 2.7.10.2

NP_001155838.1

EC 2.7.10.2

NP_001347162.1

EC 2.7.10.2

NP_766086.2

EC 2.7.10.2

XP_017171415.1

EC 2.7.10.2

XP_017171416.1

EC 2.7.10.2

XP_017171417.1

EC 2.7.10.2

XP_017171418.1

EC 2.7.10.2

XP_017171419.1

EC 2.7.10.2

XP_036014417.1

EC 2.7.10.2

XP_036014418.1

EC 2.7.10.2

XP_036014419.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162365.1 → NP_001155837.1 protein-tyrosine kinase 2-beta isoform 2

See identical proteins and their annotated locations for NP_001155837.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AC140329, AK150105, BY204086, CD775714

Consensus CDS

CCDS49525.1

UniProtKB/TrEMBL

Q3UDE9, Q8C2G0

Related

ENSMUSP00000106750.2, ENSMUST00000111121.2

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:868 → 997

Focal_AT; Focal adhesion targeting region
NM_001162366.2 → NP_001155838.1 protein-tyrosine kinase 2-beta isoform 1

See identical proteins and their annotated locations for NP_001155838.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same isoform (1).

Source sequence(s)

AC140329, AI181574, AK150105, BY203814, BY206153, CD775714

Consensus CDS

CCDS49526.1

UniProtKB/Swiss-Prot

B2RQ16, G3X8V1, Q9QVP9

UniProtKB/TrEMBL

K7QD41, Q8C2G0

Related

ENSMUSP00000022622.8, ENSMUST00000022622.14

Conserved Domains (4) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:872 → 1001

Focal_AT; Focal adhesion targeting region
NM_001360233.1 → NP_001347162.1 protein-tyrosine kinase 2-beta isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (1).

Source sequence(s)

AC140329, AI181574, AK150105, BY203814, CD775714

Consensus CDS

CCDS49526.1

UniProtKB/Swiss-Prot

B2RQ16, G3X8V1, Q9QVP9

UniProtKB/TrEMBL

K7QD41, Q8C2G0

Related

ENSMUSP00000137008.2, ENSMUST00000178730.8

Conserved Domains (4) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:872 → 1001

Focal_AT; Focal adhesion targeting region
NM_172498.3 → NP_766086.2 protein-tyrosine kinase 2-beta isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.

Source sequence(s)

AA462640, AC140329, AK150105, BY204086, CD775714

Consensus CDS

CCDS27220.1

UniProtKB/TrEMBL

E9Q2A6, Q8C2G0

Related

ENSMUSP00000086661.3, ENSMUST00000089250.9

Conserved Domains (6) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00219
Location:425 → 679

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:150 → 254

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:830 → 959

Focal_AT; Focal adhesion targeting region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

66390706..66518549 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315926.2 → XP_017171415.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/TrEMBL

Q8C2G0

Conserved Domains (5) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:883 → 1012

Focal_AT; Focal adhesion targeting region

pfam18038
Location:39 → 137

FERM_N_2; FERM N-terminal domain
XM_017315930.3 → XP_017171419.1 protein-tyrosine kinase 2-beta isoform X2

UniProtKB/TrEMBL

Q8C2G0

Conserved Domains (5) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:841 → 970

Focal_AT; Focal adhesion targeting region

pfam18038
Location:39 → 137

FERM_N_2; FERM N-terminal domain
XM_036158524.1 → XP_036014417.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/TrEMBL

Q8C2G0

Conserved Domains (5) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:883 → 1012

Focal_AT; Focal adhesion targeting region

pfam18038
Location:39 → 137

FERM_N_2; FERM N-terminal domain
XM_036158525.1 → XP_036014418.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/TrEMBL

Q8C2G0

Conserved Domains (5) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:883 → 1012

Focal_AT; Focal adhesion targeting region

pfam18038
Location:39 → 137

FERM_N_2; FERM N-terminal domain
XM_017315929.2 → XP_017171418.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/TrEMBL

Q8C2G0

Conserved Domains (5) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:883 → 1012

Focal_AT; Focal adhesion targeting region

pfam18038
Location:39 → 137

FERM_N_2; FERM N-terminal domain
XM_017315927.2 → XP_017171416.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/TrEMBL

Q8C2G0

Conserved Domains (5) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:883 → 1012

Focal_AT; Focal adhesion targeting region

pfam18038
Location:39 → 137

FERM_N_2; FERM N-terminal domain
XM_036158526.1 → XP_036014419.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/TrEMBL

Q8C2G0

Conserved Domains (5) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:883 → 1012

Focal_AT; Focal adhesion targeting region

pfam18038
Location:39 → 137

FERM_N_2; FERM N-terminal domain
XM_017315928.2 → XP_017171417.1 protein-tyrosine kinase 2-beta isoform X1

UniProtKB/TrEMBL

Q8C2G0

Conserved Domains (5) summary

cd05056
Location:418 → 687

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:41 → 254

B41; Band 4.1 homologues

cd13190
Location:261 → 368

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:883 → 1012

Focal_AT; Focal adhesion targeting region

pfam18038
Location:39 → 137

FERM_N_2; FERM N-terminal domain