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    Cilp cartilage intermediate layer protein, nucleotide pyrophosphohydrolase [ Mus musculus (house mouse) ]

    Gene ID: 214425, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cilpprovided by MGI
    Official Full Name
    cartilage intermediate layer protein, nucleotide pyrophosphohydrolaseprovided by MGI
    Primary source
    MGI:MGI:2444507
    See related
    Ensembl:ENSMUSG00000042254 AllianceGenome:MGI:2444507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CILP-1; 9830114D16; C130036G17Rik
    Summary
    Predicted to be involved in negative regulation of gene expression and negative regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cerebral cortex; diaphragm; lower lip; musculoskeletal system; and spleen. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human CILP (cartilage intermediate layer protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 10.5), subcutaneous fat pad adult (RPKM 8.2) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cilp in Genome Data Viewer
    Location:
    9 C; 9 35.2 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65172462..65187896)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65265180..65280614)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2894 Neighboring gene predicted gene, 40527 Neighboring gene RNA, U5G small nuclear Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65064991-65065144 Neighboring gene poly (ADP-ribose) polymerase family, member 16 Neighboring gene predicted gene, 36538 Neighboring gene STARR-seq mESC enhancer starr_24450 Neighboring gene STARR-positive B cell enhancer ABC_E5079 Neighboring gene predicted gene 16218 Neighboring gene caseinolytic mitochondrial matrix peptidase chaperone subunit Neighboring gene predicted gene, 19219

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    cartilage intermediate layer protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364527.1NP_001351456.1  cartilage intermediate layer protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110235
      UniProtKB/Swiss-Prot
      Q66K08, Q7TSS0, Q7TSS1, Q8BV01
      Conserved Domains (3) summary
      smart00209
      Location:53101
      TSP1; Thrombospondin type 1 repeats
      pfam13330
      Location:140
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      pfam13927
      Location:210279
      Ig_3; Immunoglobulin domain
    2. NM_173385.3NP_775561.1  cartilage intermediate layer protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_775561.1

      Status: VALIDATED

      Source sequence(s)
      AC110235, AK081544
      Consensus CDS
      CCDS23287.1
      UniProtKB/Swiss-Prot
      Q66K08, Q7TSS0, Q7TSS1, Q8BV01
      UniProtKB/TrEMBL
      A0A0R4J0F8
      Related
      ENSMUSP00000036631.2, ENSMUST00000048762.8
      Conserved Domains (5) summary
      smart00408
      Location:323383
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:152200
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:321394
      IG_like; Immunoglobulin like
      pfam13330
      Location:55139
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      pfam13715
      Location:492580
      CarbopepD_reg_2; CarboxypepD_reg-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65172462..65187896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)