U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cacybp calcyclin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 12301, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cacybpprovided by MGI
    Official Full Name
    calcyclin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1270839
    See related
    Ensembl:ENSMUSG00000014226 AllianceGenome:MGI:1270839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIP
    Summary
    Enables molecular adaptor activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm and nuclear envelope lumen. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; liver lobe; nervous system; and sensory organ. Orthologous to human CACYBP (calcyclin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 42.1), liver E14 (RPKM 32.8) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cacybp in Genome Data Viewer
    Location:
    1 H2.1; 1 69.61 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160029171..160040391, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (160202367..160212892, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53640 Neighboring gene tenascin N Neighboring gene STARR-seq mESC enhancer starr_02794 Neighboring gene RIKEN cDNA 4933417C20 gene Neighboring gene STARR-seq mESC enhancer starr_02795 Neighboring gene STARR-seq mESC enhancer starr_02796 Neighboring gene STARR-seq mESC enhancer starr_02797 Neighboring gene STARR-seq mESC enhancer starr_02798 Neighboring gene STARR-positive B cell enhancer ABC_E9188 Neighboring gene STARR-positive B cell enhancer ABC_E5830 Neighboring gene STARR-positive B cell enhancer ABC_E5831 Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene RAB GTPase activating protein 1-like Neighboring gene STARR-seq mESC enhancer starr_02799 Neighboring gene STARR-seq mESC enhancer starr_02800 Neighboring gene microRNA 1927

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S100 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to growth hormone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of beta-catenin destruction complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    calcyclin-binding protein
    Names
    siah-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426712.1NP_001413641.1  calcyclin-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154873
    2. NM_001426713.1NP_001413642.1  calcyclin-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154873
    3. NM_009786.3NP_033916.1  calcyclin-binding protein isoform 1

      See identical proteins and their annotated locations for NP_033916.1

      Status: VALIDATED

      Source sequence(s)
      AC154873
      Consensus CDS
      CCDS15406.1
      UniProtKB/Swiss-Prot
      O70140, Q9CXW3
      Related
      ENSMUSP00000014370.6, ENSMUST00000014370.11
      Conserved Domains (3) summary
      cd06468
      Location:76168
      p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
      pfam05002
      Location:183218
      SGS; SGS domain
      pfam09032
      Location:576
      Siah-Interact_N; Siah interacting protein, N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      160029171..160040391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)