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    Zeb1 zinc finger E-box binding homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 21417, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zeb1provided by MGI
    Official Full Name
    zinc finger E-box binding homeobox 1provided by MGI
    Primary source
    MGI:MGI:1344313
    See related
    Ensembl:ENSMUSG00000024238 AllianceGenome:MGI:1344313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tw; BZP; ZEB; MEB1; Nil2; Tcf8; AREB6; TCF-8; Tcf18; Zfhep; Zfx1a; Zfhx1a; Zfx1ha; [delta]EF1; 3110032K11Rik
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuron differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; negative regulation of keratinocyte proliferation; and regulation of T cell differentiation in thymus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.2), limb E14.5 (RPKM 8.6) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zeb1 in Genome Data Viewer
    Location:
    18 4.42 cM; 18 A1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (5591330..5775468)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (5591327..5775468)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43695 Neighboring gene predicted gene, 34630 Neighboring gene STARR-seq mESC enhancer starr_43697 Neighboring gene zinc finger E-box binding homeobox 1, opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:5591157-5591340 Neighboring gene STARR-positive B cell enhancer mm9_chr18:5591593-5591893 Neighboring gene predicted gene, 52340 Neighboring gene predicted gene 2238 Neighboring gene STARR-seq mESC enhancer starr_43699 Neighboring gene predicted gene, 34740 Neighboring gene predicted gene, 34804

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cochlea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within semicircular canal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger E-box-binding homeobox 1
    Names
    transcription factor 8
    twirler
    zinc finger homeobox protein 1a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360981.1NP_001347910.1  zinc finger E-box-binding homeobox 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127028, AC138619
      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (4) summary
      smart00389
      Location:554590
      HOX; Homeodomain
      sd00017
      Location:867887
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:203225
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:907932
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001360982.1NP_001347911.1  zinc finger E-box-binding homeobox 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127028, AC138619
      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    3. NM_011546.3NP_035676.1  zinc finger E-box-binding homeobox 1 isoform 1

      See identical proteins and their annotated locations for NP_035676.1

      Status: VALIDATED

      Source sequence(s)
      AC127028, AK034821, BC139769, BE852657
      Consensus CDS
      CCDS29039.1
      UniProtKB/Swiss-Prot
      A4QPD2, Q62519, Q64318
      UniProtKB/TrEMBL
      A4QPD1
      Related
      ENSMUSP00000025081.6, ENSMUST00000025081.13
      Conserved Domains (4) summary
      smart00389
      Location:571607
      HOX; Homeodomain
      sd00017
      Location:884904
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:924949
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      5591330..5775468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250410.2XP_030106270.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    2. XM_030250409.2XP_030106269.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    3. XM_030250411.2XP_030106271.1  zinc finger E-box-binding homeobox 1 isoform X4

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (4) summary
      smart00389
      Location:504540
      HOX; Homeodomain
      sd00017
      Location:817837
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:153175
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:857882
      zf-H2C2_2; Zinc-finger double domain
    4. XM_036161065.1XP_036016958.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    5. XM_030250401.1XP_030106261.1  zinc finger E-box-binding homeobox 1 isoform X1

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:877897
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:213235
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:917942
      zf-H2C2_2; Zinc-finger double domain
    6. XM_030250405.2XP_030106265.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    7. XM_030250400.2XP_030106260.1  zinc finger E-box-binding homeobox 1 isoform X1

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:877897
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:213235
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:917942
      zf-H2C2_2; Zinc-finger double domain
    8. XM_030250406.2XP_030106266.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    9. XM_036161061.1XP_036016954.1  zinc finger E-box-binding homeobox 1 isoform X1

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:877897
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:213235
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:917942
      zf-H2C2_2; Zinc-finger double domain
    10. XM_006525769.4XP_006525832.1  zinc finger E-box-binding homeobox 1 isoform X1

      See identical proteins and their annotated locations for XP_006525832.1

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:877897
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:213235
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:917942
      zf-H2C2_2; Zinc-finger double domain
    11. XM_036161062.1XP_036016955.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    12. XM_036161059.1XP_036016952.1  zinc finger E-box-binding homeobox 1 isoform X1

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:877897
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:213235
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:917942
      zf-H2C2_2; Zinc-finger double domain
    13. XM_030250407.2XP_030106267.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    14. XM_030250404.2XP_030106264.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    15. XM_036161068.1XP_036016961.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    16. XM_036161067.1XP_036016960.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    17. XM_030250402.2XP_030106262.1  zinc finger E-box-binding homeobox 1 isoform X2

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (4) summary
      smart00389
      Location:557593
      HOX; Homeodomain
      sd00017
      Location:870890
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:206228
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:910935
      zf-H2C2_2; Zinc-finger double domain
    18. XM_030250399.2XP_030106259.1  zinc finger E-box-binding homeobox 1 isoform X1

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:877897
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:213235
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:917942
      zf-H2C2_2; Zinc-finger double domain
    19. XM_036161066.1XP_036016959.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    20. XM_036161069.1XP_036016962.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    21. XM_036161063.1XP_036016956.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    22. XM_036161064.1XP_036016957.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain
    23. XM_036161070.1XP_036016963.1  zinc finger E-box-binding homeobox 1 isoform X3

      UniProtKB/TrEMBL
      A4QPD1
      Conserved Domains (3) summary
      sd00017
      Location:828848
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:164186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:868893
      zf-H2C2_2; Zinc-finger double domain