Fcho2 FCH domain only 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcho2provided by MGI
Official Full Name: FCH domain only 2provided by MGI
Primary source: MGI:MGI:3505790
See related: Ensembl:ENSMUSG00000041685 AllianceGenome:MGI:3505790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5832424M12Rik
Summary: Enables identical protein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and phosphatidylserine binding activity. Involved in membrane invagination; protein localization to plasma membrane; and synaptic vesicle endocytosis. Located in clathrin-coated vesicle and plasma membrane. Is active in clathrin-coated pit. Is expressed in endolymphatic appendage and head. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 10.4), placenta adult (RPKM 8.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 52.16 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (98859914..98953085, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (98723406..98816577, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FCHO2 regulates clathrin-mediated endocytosis through its interactions with membranes and Eps15.
Title: Characterization of the EFC/F-BAR domain protein, FCHO2.
study reports FCHo1/2 were required for plasma membrane clathrin-coated vesicle (CCV) budding & marked sites of CCV formation
Title: FCHo proteins are nucleators of clathrin-mediated endocytosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237089

NoName (e-PCR)
- UniSTS:237092

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in clathrin coat assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in clathrin-dependent endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane invagination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in clathrin-coated pit	IBA Inferred from Biological aspect of Ancestor more info
is_active_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
NOT colocalizes_with clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in presynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-BAR domain only protein 2

Names: FCH domain only protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172591.3 → NP_766179.2 F-BAR domain only protein 2

See identical proteins and their annotated locations for NP_766179.2

Status: VALIDATED

Source sequence(s)

BB620239, BC052456, BE625696

Consensus CDS

CCDS56897.1

UniProtKB/Swiss-Prot

Q3UJ91, Q3UQN2, Q7TMS9, Q8C0I2

Related

ENSMUSP00000042959.9, ENSMUST00000040340.16

Conserved Domains (2) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cd09267
Location:543 → 809

FCHo2_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

98859914..98953085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244652.4 → XP_011242954.1 F-BAR domain only protein 2 isoform X1

Conserved Domains (3) summary

cd07673
Location:5 → 248

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cd09267
Location:518 → 784

FCHo2_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins

pfam15685
Location:423 → 476

GGN; Gametogenetin