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    Cercam cerebral endothelial cell adhesion molecule [ Mus musculus (house mouse) ]

    Gene ID: 99151, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cercamprovided by MGI
    Official Full Name
    cerebral endothelial cell adhesion moleculeprovided by MGI
    Primary source
    MGI:MGI:2139134
    See related
    Ensembl:ENSMUSG00000039787 AllianceGenome:MGI:2139134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ceecam1; 2600006K01Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum lumen. Is expressed in brain ventricular layer; clavicle; craniocervical region bone; and ventral grey horn. Orthologous to human CERCAM (cerebral endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 10.7), limb E14.5 (RPKM 10.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cercam in Genome Data Viewer
    Location:
    2 B; 2 20.76 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29735442..29772857)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29845094..29882840)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 (fatty acid transporter), member 4 Neighboring gene STARR-seq mESC enhancer starr_04075 Neighboring gene STARR-positive B cell enhancer ABC_E224 Neighboring gene ubiquitin related modifier 1 Neighboring gene microRNA 219a-2 Neighboring gene predicted gene, 54109 Neighboring gene microRNA 219b Neighboring gene RIKEN cDNA 2600006K01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29724576-29724685 Neighboring gene STARR-positive B cell enhancer ABC_E1583 Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene STARR-positive B cell enhancer ABC_E4425 Neighboring gene GLE1 RNA export mediator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development. Moulson CL, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12697906, Free PMC Article
    2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables procollagen galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inactive glycosyltransferase 25 family member 3
    Names
    cerebral endothelial cell adhesion molecule 1
    glycosyltransferase 25 family member 3
    probable inactive glycosyltransferase 25 family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207298.2 → NP_997181.1  inactive glycosyltransferase 25 family member 3 precursor

      See identical proteins and their annotated locations for NP_997181.1

      Status: VALIDATED

      Source sequence(s)
      AL928926
      Consensus CDS
      CCDS15860.1
      UniProtKB/Swiss-Prot
      A3KGW5
      UniProtKB/TrEMBL
      B2RSF7
      Related
      ENSMUSP00000041622.7, ENSMUST00000047521.7
      Conserved Domains (2) summary
      cd00761
      Location:34 → 157
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
      cd06532
      Location:318 → 500
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29735442..29772857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498476.5 → XP_006498539.1  inactive glycosyltransferase 25 family member 3 isoform X2

      See identical proteins and their annotated locations for XP_006498539.1

      Conserved Domains (1) summary
      cd06532
      Location:249 → 431
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    2. XM_006498475.5 → XP_006498538.1  inactive glycosyltransferase 25 family member 3 isoform X1

      Conserved Domains (1) summary
      cd06532
      Location:283 → 465
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    3. XM_006498478.3 → XP_006498541.1  inactive glycosyltransferase 25 family member 3 isoform X3

      Conserved Domains (1) summary
      cd06532
      Location:63 → 245
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    4. XM_017319356.3 → XP_017174845.1  inactive glycosyltransferase 25 family member 3 isoform X3

      Conserved Domains (1) summary
      cd06532
      Location:63 → 245
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KGW5.1 GenPept UniProtKB/Swiss-Prot:A3KGW5

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