Vrk1 vaccinia related kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vrk1provided by MGI
Official Full Name: vaccinia related kinase 1provided by MGI
Primary source: MGI:MGI:1261847
See related: Ensembl:ENSMUSG00000021115 AllianceGenome:MGI:1261847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 51PK; Gm40568; Gm46378
Summary: Enables protein serine/threonine kinase activity. Involved in regulation of neuron migration. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 11.6), CNS E11.5 (RPKM 9.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E- F1; 12 56.37 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (105976398..106044578)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (106010139..106078318)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VRK1 promotes DNA-induced type I interferon production.
Title: VRK1 promotes DNA-induced type I interferon production.
Ginsenoside Rg3 upregulate VRK1 expression and P53BP1 foci formation in response to DNA damage.
Title: Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway.
Together, these studies of the partial KO Vrk1 mice reveal that even moderately reduced levels of Vrk1 expression result in minor neurological impairment and indicate new neuronal pathways likely involving VRK1.
Title: Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways.
VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
Title: Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP). APP overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP-dependent mechanism.
Title: The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-β precursor protein-dependent mechanism.
Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.
Title: Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1.
Protein kinase Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53-dependent manner.
Title: Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.
reduction of VRK1 activity causes a delay in meiotic progression during oogenesis
Title: The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis.
VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance
Title: Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells.
Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.
Title: Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Vrk1 (e-PCR), detects polymorphism
- UniSTS:265686

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AX kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AX kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleosomal DNA binding	ISO Inferred from Sequence Orthology more info
enables nucleosomal DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Cajal body organization	ISO Inferred from Sequence Orthology more info
involved_in Cajal body organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi disassembly	ISO Inferred from Sequence Orthology more info
involved_in Golgi disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to chromatin	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in Cajal body	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase VRK1

Names: serine/threonine-protein kinase 51PK

NP_001025014.1

EC 2.7.11.1

NP_001025015.1

EC 2.7.11.1

NP_001351294.1

EC 2.7.11.1

NP_001351296.1

EC 2.7.11.1

NP_001351297.1

EC 2.7.11.1

NP_001409909.1

EC 2.7.11.1

NP_035835.1

EC 2.7.11.1

XP_006515872.1

EC 2.7.11.1

XP_006515873.1

EC 2.7.11.1

XP_006515874.1

EC 2.7.11.1

XP_011242406.1

EC 2.7.11.1

XP_017170534.1

EC 2.7.11.1

XP_030102545.1

EC 2.7.11.1

XP_030102546.1

EC 2.7.11.1

XP_030102547.1

EC 2.7.11.1

XP_030102548.1

EC 2.7.11.1

XP_030102549.1

EC 2.7.11.1

XP_030102550.1

EC 2.7.11.1

XP_030102551.1

EC 2.7.11.1

XP_030102553.1

EC 2.7.11.1

XP_030102554.1

EC 2.7.11.1

XP_030102556.1

EC 2.7.11.1

XP_036013274.1

EC 2.7.11.1

XP_036013275.1

EC 2.7.11.1

XP_036013276.1

EC 2.7.11.1

XP_036013277.1

EC 2.7.11.1

XP_036013278.1

EC 2.7.11.1

XP_036013279.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029843.2 → NP_001025014.1 serine/threonine-protein kinase VRK1 isoform b

See identical proteins and their annotated locations for NP_001025014.1

Status: VALIDATED

Source sequence(s)

AK032344, AV567830, BY130767

Consensus CDS

CCDS26157.1

UniProtKB/TrEMBL

Q3TL56, Q3UWH3

Related

ENSMUSP00000082101.5, ENSMUST00000085026.12

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
NM_001029844.2 → NP_001025015.1 serine/threonine-protein kinase VRK1 isoform c

See identical proteins and their annotated locations for NP_001025015.1

Status: VALIDATED

Source sequence(s)

AK032344, AV567830, BY130767

Consensus CDS

CCDS26158.1

UniProtKB/TrEMBL

Q3TL56

Related

ENSMUSP00000071922.6, ENSMUST00000072040.7

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
NM_001364365.1 → NP_001351294.1 serine/threonine-protein kinase VRK1 isoform c

Status: VALIDATED

Source sequence(s)

AC144543, AC163040

Consensus CDS

CCDS26158.1

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
NM_001364367.1 → NP_001351296.1 serine/threonine-protein kinase VRK1 isoform a

Status: VALIDATED

Source sequence(s)

AC144543, AC163040

Consensus CDS

CCDS36551.1

UniProtKB/Swiss-Prot

O88635, O88636, Q80X41, Q8C2P7, Q91YH9

UniProtKB/TrEMBL

Q3TL56

Related

ENSMUSP00000152109.2, ENSMUST00000220629.2

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
NM_001364368.1 → NP_001351297.1 serine/threonine-protein kinase VRK1 isoform d

Status: VALIDATED

Source sequence(s)

AC144543, AC163040

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 324

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
NM_001422980.1 → NP_001409909.1 serine/threonine-protein kinase VRK1 isoform e

Status: VALIDATED

Source sequence(s)

AC144543, AC163040
NM_011705.4 → NP_035835.1 serine/threonine-protein kinase VRK1 isoform a

See identical proteins and their annotated locations for NP_035835.1

Status: VALIDATED

Source sequence(s)

AK032344, AV567830, BB749810, BY130767

Consensus CDS

CCDS36551.1

UniProtKB/Swiss-Prot

O88635, O88636, Q80X41, Q8C2P7, Q91YH9

UniProtKB/TrEMBL

Q3TL56

Related

ENSMUSP00000021539.9, ENSMUST00000021539.16

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

105976398..106044578

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246689.1 → XP_030102549.1 serine/threonine-protein kinase VRK1 isoform X6

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_006515810.5 → XP_006515873.1 serine/threonine-protein kinase VRK1 isoform X2

See identical proteins and their annotated locations for XP_006515873.1

UniProtKB/Swiss-Prot

O88635, O88636, Q80X41, Q8C2P7, Q91YH9

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_030246687.2 → XP_030102547.1 serine/threonine-protein kinase VRK1 isoform X4

UniProtKB/TrEMBL

Q3TL56, Q3UWH3

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_036157384.1 → XP_036013277.1 serine/threonine-protein kinase VRK1 isoform X8

Conserved Domains (1) summary

cl21453
Location:26 → 206

PKc_like; Protein Kinases, catalytic domain
XM_030246693.2 → XP_030102553.1 serine/threonine-protein kinase VRK1 isoform X8

Conserved Domains (1) summary

cl21453
Location:26 → 206

PKc_like; Protein Kinases, catalytic domain
XM_006515811.5 → XP_006515874.1 serine/threonine-protein kinase VRK1 isoform X2

See identical proteins and their annotated locations for XP_006515874.1

UniProtKB/Swiss-Prot

O88635, O88636, Q80X41, Q8C2P7, Q91YH9

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_030246688.2 → XP_030102548.1 serine/threonine-protein kinase VRK1 isoform X5

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_036157382.1 → XP_036013275.1 serine/threonine-protein kinase VRK1 isoform X4

UniProtKB/TrEMBL

Q3TL56, Q3UWH3

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_030246685.2 → XP_030102545.1 serine/threonine-protein kinase VRK1 isoform X3

UniProtKB/TrEMBL

A0A1Y7VMH3

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_030246694.2 → XP_030102554.1 serine/threonine-protein kinase VRK1 isoform X10

Conserved Domains (1) summary

cl21453
Location:26 → 206

PKc_like; Protein Kinases, catalytic domain
XM_036157385.1 → XP_036013278.1 serine/threonine-protein kinase VRK1 isoform X11

Conserved Domains (1) summary

cl21453
Location:26 → 206

PKc_like; Protein Kinases, catalytic domain
XM_030246690.2 → XP_030102550.1 serine/threonine-protein kinase VRK1 isoform X6

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_030246696.2 → XP_030102556.1 serine/threonine-protein kinase VRK1 isoform X11

Conserved Domains (1) summary

cl21453
Location:26 → 206

PKc_like; Protein Kinases, catalytic domain
XM_036157383.1 → XP_036013276.1 serine/threonine-protein kinase VRK1 isoform X4

UniProtKB/TrEMBL

Q3TL56, Q3UWH3

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_006515809.3 → XP_006515872.1 serine/threonine-protein kinase VRK1 isoform X2

See identical proteins and their annotated locations for XP_006515872.1

UniProtKB/Swiss-Prot

O88635, O88636, Q80X41, Q8C2P7, Q91YH9

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_030246686.1 → XP_030102546.1 serine/threonine-protein kinase VRK1 isoform X4

UniProtKB/TrEMBL

Q3TL56, Q3UWH3

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_030246691.1 → XP_030102551.1 serine/threonine-protein kinase VRK1 isoform X6

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_036157381.1 → XP_036013274.1 serine/threonine-protein kinase VRK1 isoform X2

UniProtKB/Swiss-Prot

O88635, O88636, Q80X41, Q8C2P7, Q91YH9

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_017315045.3 → XP_017170534.1 serine/threonine-protein kinase VRK1 isoform X1

UniProtKB/TrEMBL

Q3TL56

Conserved Domains (1) summary

cd14122
Location:26 → 326

STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
XM_011244104.2 → XP_011242406.1 serine/threonine-protein kinase VRK1 isoform X9

Conserved Domains (1) summary

cl21453
Location:1 → 198

PKc_like; Protein Kinases, catalytic domain
XM_036157386.1 → XP_036013279.1 serine/threonine-protein kinase VRK1 isoform X12

UniProtKB/TrEMBL

Q8CA60

Conserved Domains (1) summary

cl21453
Location:1 → 198

PKc_like; Protein Kinases, catalytic domain