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    Trim26 tripartite motif-containing 26 [ Mus musculus (house mouse) ]

    Gene ID: 22670, updated on 27-Nov-2024

    Summary

    Official Symbol
    Trim26provided by MGI
    Official Full Name
    tripartite motif-containing 26provided by MGI
    Primary source
    MGI:MGI:1337056
    See related
    Ensembl:ENSMUSG00000024457 AllianceGenome:MGI:1337056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp173; Zfp1736
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of non-canonical NF-kappaB signal transduction; and protein K11-linked ubiquitination. Located in cytoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to human TRIM26 (tripartite motif containing 26). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 19.3), spleen adult (RPKM 16.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Trim26 in Genome Data Viewer
    Location:
    17 B1; 17 19.16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37148016..37170290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36837123..36859398)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 10.5 Neighboring gene histocompatibility 2, M region locus 10.6 Neighboring gene STARR-positive B cell enhancer ABC_E612 Neighboring gene predicted gene, 25973 Neighboring gene tripartite motif-containing 15 Neighboring gene tripartite motif-containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in suppression of viral release by host IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tripartite motif-containing protein 26
    Names
    tripartite motif protein 26
    tripartite motif protein TRIM26
    zinc finger protein 173
    NP_001020770.2
    NP_001273655.1
    NP_001273656.1
    XP_006524276.1
    XP_006524277.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025599.3NP_001020770.2  tripartite motif-containing protein 26

      See identical proteins and their annotated locations for NP_001020770.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate splice site in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      BC037110, BQ176978, CF168373
      Consensus CDS
      CCDS37613.1
      UniProtKB/Swiss-Prot
      B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
      UniProtKB/TrEMBL
      Q3UFX3
      Related
      ENSMUSP00000060103.8, ENSMUST00000053434.15
      Conserved Domains (3) summary
      cd15826
      Location:320544
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:1357
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
    2. NM_001286726.1NP_001273655.1  tripartite motif-containing protein 26

      See identical proteins and their annotated locations for NP_001273655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AK042252, BC037110, BQ176978, CF168373
      Consensus CDS
      CCDS37613.1
      UniProtKB/Swiss-Prot
      B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
      UniProtKB/TrEMBL
      Q3UFX3
      Conserved Domains (3) summary
      cd15826
      Location:320544
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:1357
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
    3. NM_001286727.1NP_001273656.1  tripartite motif-containing protein 26

      See identical proteins and their annotated locations for NP_001273656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate splice junction in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AK148247, BC037110, BQ176978, CF168373
      Consensus CDS
      CCDS37613.1
      UniProtKB/Swiss-Prot
      B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
      UniProtKB/TrEMBL
      Q3UFX3
      Related
      ENSMUSP00000114896.2, ENSMUST00000130367.8
      Conserved Domains (3) summary
      cd15826
      Location:320544
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:1357
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37148016..37170290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524214.4XP_006524277.1  tripartite motif-containing protein 26 isoform X2

      See identical proteins and their annotated locations for XP_006524277.1

      UniProtKB/TrEMBL
      Q3UFX3
      Conserved Domains (3) summary
      cd15826
      Location:314538
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:1357
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
    2. XM_006524213.4XP_006524276.1  tripartite motif-containing protein 26 isoform X1

      See identical proteins and their annotated locations for XP_006524276.1

      UniProtKB/Swiss-Prot
      B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
      UniProtKB/TrEMBL
      Q3UFX3
      Conserved Domains (3) summary
      cd15826
      Location:320544
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:1357
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030698.4: Suppressed sequence

      Description
      NM_030698.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.