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    Oxa1l oxidase assembly 1-like [ Mus musculus (house mouse) ]

    Gene ID: 69089, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oxa1lprovided by MGI
    Official Full Name
    oxidase assembly 1-likeprovided by MGI
    Primary source
    MGI:MGI:1916339
    See related
    Ensembl:ENSMUSG00000000959 AllianceGenome:MGI:1916339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810020M02Rik
    Summary
    Predicted to enable membrane insertase activity; mitochondrial ribosome binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial protein quality control; mitochondrion organization; and protein tetramerization. Located in mitochondrial inner membrane. Orthologous to human OXA1L (OXA1L mitochondrial inner membrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 141.2), ovary adult (RPKM 84.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Oxa1l in Genome Data Viewer
    Location:
    14 C2; 14 27.76 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54598298..54607130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54360841..54369669)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 43305 Neighboring gene eukaryotic translation initiation factor 4H pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3114 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 Neighboring gene STARR-seq mESC enhancer starr_36728 Neighboring gene STARR-positive B cell enhancer ABC_E3115 Neighboring gene STARR-seq mESC enhancer starr_36729 Neighboring gene STARR-seq mESC enhancer starr_36730 Neighboring gene STARR-seq mESC enhancer starr_36733 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene matrix metallopeptidase 14 (membrane-inserted)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables membrane insertase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables membrane insertase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mitochondrial ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitochondrial ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial protein quality control ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial protein quality control ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein insertion into mitochondrial inner membrane from matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein insertion into mitochondrial inner membrane from matrix ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein insertion into mitochondrial inner membrane from matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein tetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial inner membrane protein OXA1L
    Names
    OXA1-like protein
    oxidase assembly 1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026936.4NP_081212.1  mitochondrial inner membrane protein OXA1L

      See identical proteins and their annotated locations for NP_081212.1

      Status: VALIDATED

      Source sequence(s)
      AC206013
      Consensus CDS
      CCDS27086.1
      UniProtKB/Swiss-Prot
      Q8BGA9, Q8BK01, Q8R091, Q9D8X7
      UniProtKB/TrEMBL
      Q3UTE7
      Related
      ENSMUSP00000000985.6, ENSMUST00000000985.7
      Conserved Domains (1) summary
      COG0706
      Location:74324
      YidC; Membrane protein insertase Oxa1/YidC/SpoIIIJ, required for the localization of integral membrane proteins [Cell wall/membrane/envelope biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54598298..54607130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)