Slc46a2 solute carrier family 46, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc46a2provided by MGI
Official Full Name: solute carrier family 46, member 2provided by MGI
Primary source: MGI:MGI:1353616
See related: Ensembl:ENSMUSG00000028386 AllianceGenome:MGI:1353616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly110; Tscot; TSO-1C12; 5430429N04Rik
Summary: Predicted to enable cyclic-GMP-AMP transmembrane transporter activity. Acts upstream of or within several processes, including T cell homeostasis; negative regulation of T cell apoptotic process; and thymus development. Located in cell surface. Is expressed in several structures, including foregut gland; hemolymphoid system; and skin. Orthologous to human SLC46A2 (solute carrier family 46 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 10.5), genital fat pad adult (RPKM 6.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 32.81 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (59905899..59915056, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (59905899..59915056, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression profiling of thymic stromal cotransporter (TSCOT), Slc46A2/Ly110, that was shown to be expressed in bipotent precursor and cortical thymic epithelial cells.
Title: Expression Analyses Revealed Thymic Stromal Co-Transporter/Slc46A2 Is in Stem Cell Populations and Is a Putative Tumor Suppressor.
Thymic epithelial requirement for gammadelta T cell development revealed in the cell ablation transgenic system with TSCOT promoter
Title: Thymic epithelial requirement for γδ T cell development revealed in the cell ablation transgenic system with TSCOT promoter.
the introduction of a neoantigen into TSCOT-expressing cells can efficiently establish complete tolerance and suggest a possible application for the deletion of antigen-specific T cells by antigen introduction into TSCOT+ cells.
Title: TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

Slc46a2 (e-PCR), detects polymorphism
- UniSTS:547119

Slc46a2 (e-PCR), detects polymorphism
- UniSTS:527067

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclic-GMP-AMP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cyclic-GMP-AMP transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of T cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thymus development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: solute carrier family 46 member 2

Names: putative thymic stromal co-transporter TSCOT; thymic stromal cotransporter homolog; thymic stromal cotransporter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021053.4 → NP_066395.3 solute carrier family 46 member 2

See identical proteins and their annotated locations for NP_066395.3

Status: VALIDATED

Source sequence(s)

AK040063, AL831738

Consensus CDS

CCDS18227.1

UniProtKB/Swiss-Prot

A2ANT4, Q8CA03, Q9D3J2, Q9JLQ3

UniProtKB/TrEMBL

A9R9W2

Related

ENSMUSP00000030081.2, ENSMUST00000030081.2

Conserved Domains (2) summary

cd06174
Location:86 → 455

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:88 → 422

MFS_1; Major Facilitator Superfamily