Adra2a adrenergic receptor, alpha 2a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adra2aprovided by MGI
Official Full Name: adrenergic receptor, alpha 2aprovided by MGI
Primary source: MGI:MGI:87934
See related: Ensembl:ENSMUSG00000033717 AllianceGenome:MGI:87934
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adra-2; Adra-2a; alpha2A; alpha2-C10; alpha2A-AR; alpha(2A)AR
Summary: Enables alpha2-adrenergic receptor activity. Involved in negative regulation of insulin secretion and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within G protein-coupled receptor signaling pathway and fear response. Is active in dopaminergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; familial partial lipodystrophy; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 49.04 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (54033690..54037413)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (54045259..54048982)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor alpha2A.
Title: Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α(2A).
The alpha2-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.
Title: The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.
Heteromerization between alpha2A adrenoceptors and different polymorphic variants of the dopamine D4 receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.
Title: Heteromerization between α(2A) adrenoceptors and different polymorphic variants of the dopamine D(4) receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.
Role of alpha2-Adrenoceptor Subtypes in Suppression of L-Type Ca(2+) Current in Mouse Cardiac Myocytes.
Title: Role of α2-Adrenoceptor Subtypes in Suppression of L-Type Ca(2+) Current in Mouse Cardiac Myocytes.
alpha2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome.
Title: α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome.
The in vivo specificity of synaptic Gbeta and Ggamma subunits to the alpha2a adrenergic receptor at CNS synapses.
Title: The in vivo specificity of synaptic Gβ and Gγ subunits to the α(2a) adrenergic receptor at CNS synapses.
Study shows that dorsal BNST alpha2A-adrenergic receptors produce HCN-dependent excitatory actions that initiate anxiogenic behaviors.
Title: Dorsal BNST α(2A)-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
Lack of alpha2A-ARs protects from diet-induced obesity and type 2 diabetes (T2D). Blockade of alpha2A-ARs may be exploited to reduce visceral fat and to improve insulin secretion.
Title: Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors.
We show that these neurons are dispensable for regulating food intake, but are required for coordinating hepatic glucose production and for the fasting-induced fall in leptin levels, independent of changes in fat mass. We also identify a role for sympathetic nervous system regulation of the inhibitory adrenergic receptor (ADRA2A) in regulating leptin production.
Title: POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels.
Study showed that alpha2A adrenergic receptors are highly expressed in the cell bodies and axons of mesoprefrontal dopaminergic neurons provides a morphological basis to the vast functional evidence that somatodendritic and nerve-terminal alpha2A adrenergic receptors control dopaminergic activity and dopamine release in the prefrontal cortex.
Title: α2A adrenergic receptors highly expressed in mesoprefrontal dopamine neurons.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (6)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adrenergic receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-2C adrenergic receptor binding	IEA Inferred from Electronic Annotation more info
enables alpha-2C adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha2-adrenergic receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha2-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables alpha2-adrenergic receptor activity	TAS Traceable Author Statement more info	PubMed
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	IEA Inferred from Electronic Annotation more info
enables epinephrine binding	ISO Inferred from Sequence Orthology more info
enables heterotrimeric G-protein binding	IEA Inferred from Electronic Annotation more info
enables heterotrimeric G-protein binding	ISO Inferred from Sequence Orthology more info
enables norepinephrine binding	IEA Inferred from Electronic Annotation more info
enables norepinephrine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	IEA Inferred from Electronic Annotation more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion-dependent exocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of uterine smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor transactivation	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in response to alcohol	IEA Inferred from Electronic Annotation more info
involved_in response to morphine	IEA Inferred from Electronic Annotation more info
involved_in thermoception	IEA Inferred from Electronic Annotation more info
involved_in thermoception	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-2A adrenergic receptor

Names: alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha2A-adrenergic receptor; subtype alpha2-C10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007417.5 → NP_031443.4 alpha-2A adrenergic receptor

See identical proteins and their annotated locations for NP_031443.4

Status: VALIDATED

Source sequence(s)

AC113491

Consensus CDS

CCDS29905.1

UniProtKB/Swiss-Prot

Q01338, Q3URE6

UniProtKB/TrEMBL

Q1HL33

Related

ENSMUSP00000036203.6, ENSMUST00000036700.7

Conserved Domains (1) summary

cd15322
Location:49 → 452

7tmA_alpha2A_AR; alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors