Trim44 tripartite motif-containing 44 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim44provided by MGI
Official Full Name: tripartite motif-containing 44provided by MGI
Primary source: MGI:MGI:1931835
See related: Ensembl:ENSMUSG00000027189 AllianceGenome:MGI:1931835
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mc7; Dipb
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of protein K48-linked ubiquitination; positive regulation of defense response to virus by host; and positive regulation of signal transduction. Predicted to be active in cytoplasm. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human TRIM44 (tripartite motif containing 44). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 39.5), CNS E18 (RPKM 31.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.13 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (102130464..102231541, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (102300119..102400900, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism.
Title: TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism.
TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis.
Title: TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis.
Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma.
Title: Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma.
terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein.
Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

AI579384 (e-PCR)
- UniSTS:249356

UniSTS:234475 (e-PCR)
- UniSTS:234475

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing protein 44

Names: DIPB; brain cDNA 7; protein Mc7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020267.3 → NP_064663.2 tripartite motif-containing protein 44

See identical proteins and their annotated locations for NP_064663.2

Status: VALIDATED

Source sequence(s)

AL691444

Consensus CDS

CCDS16466.1

UniProtKB/Swiss-Prot

Q80SV9, Q9JHR8, Q9QXA7

UniProtKB/TrEMBL

Q4KMS1

Related

ENSMUSP00000099633.2, ENSMUST00000102573.8

Conserved Domains (1) summary

pfam00643
Location:177 → 216

zf-B_box; B-box zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

102130464..102231541 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_029448.1: Suppressed sequence

Description

NM_029448.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.