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    Saxo4 stabilizer of axonemal microtubules 4 [ Mus musculus (house mouse) ]

    Gene ID: 67752, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Saxo4provided by MGI
    Official Full Name
    stabilizer of axonemal microtubules 4provided by MGI
    Primary source
    MGI:MGI:1915002
    See related
    Ensembl:ENSMUSG00000035179 AllianceGenome:MGI:1915002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IIIG9; IIIG9L; IIIG9S; Ppp1r32; 4930579J09Rik
    Summary
    Predicted to enable phosphatase binding activity. Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in lung; male reproductive gland or organ; olfactory lobe; and oviduct. Orthologous to human SAXO4 (stabilizer of axonemal microtubules 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 129.8) See more
    Orthologs
    human all
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    Genomic context

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    See Saxo4 in Genome Data Viewer
    Location:
    19 A; 19 6.6 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10451599..10463826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10474235..10491451, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin VII Neighboring gene leucine rich repeat containing 10B Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel mRNA expressed along brain ventricles. Danielson PE, et al. Brain Res Gene Expr Patterns, 2002 Jan. PMID 15018803
    2. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Nguyen TTT, et al. Front Cell Dev Biol, 2024. PMID 38835510, Free PMC Article
    3. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144717

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axonemal A tubule inner sheath TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stabilizer of axonemal microtubules 4
    Names
    protein phosphatase 1, regulatory subunit 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368184.1 → NP_001355113.1  stabilizer of axonemal microtubules 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK005821, AK016325, AY032666, BX630729
      Consensus CDS
      CCDS29577.1
      UniProtKB/Swiss-Prot
      Q148A4, Q91XJ2
      UniProtKB/TrEMBL
      A0A0R4J0F3
      Related
      ENSMUSP00000158578.2, ENSMUST00000237522.2
      Conserved Domains (1) summary
      pfam15691
      Location:2 → 418
      PPP1R32; Protein phosphatase 1 regulatory subunit 32

    2. NM_133689.2 → NP_598450.1  stabilizer of axonemal microtubules 4

      See identical proteins and their annotated locations for NP_598450.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK005821, AY032666, BX630729
      Consensus CDS
      CCDS29577.1
      UniProtKB/Swiss-Prot
      Q148A4, Q91XJ2
      UniProtKB/TrEMBL
      A0A0R4J0F3
      Related
      ENSMUSP00000035684.4, ENSMUST00000038842.5
      Conserved Domains (1) summary
      pfam15691
      Location:2 → 418
      PPP1R32; Protein phosphatase 1 regulatory subunit 32

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10451599..10463826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318282.1 → XP_017173771.1  stabilizer of axonemal microtubules 4 isoform X1

      UniProtKB/Swiss-Prot
      Q148A4, Q91XJ2
      UniProtKB/TrEMBL
      A0A0R4J0F3
      Conserved Domains (1) summary
      pfam15691
      Location:2 → 418
      PPP1R32; Protein phosphatase 1 regulatory subunit 32

    2. XM_036161672.1 → XP_036017565.1  stabilizer of axonemal microtubules 4 isoform X2

      UniProtKB/TrEMBL
      A0A494B8Y3
      Related
      ENSMUSP00000157403.2, ENSMUST00000235392.2
      Conserved Domains (1) summary
      pfam15691
      Location:1 → 244
      PPP1R32; Protein phosphatase 1 regulatory subunit 32

    3. XM_017318281.1 → XP_017173770.1  stabilizer of axonemal microtubules 4 isoform X1

      UniProtKB/Swiss-Prot
      Q148A4, Q91XJ2
      UniProtKB/TrEMBL
      A0A0R4J0F3
      Conserved Domains (1) summary
      pfam15691
      Location:2 → 418
      PPP1R32; Protein phosphatase 1 regulatory subunit 32

    4. XM_006527302.5 → XP_006527365.1  stabilizer of axonemal microtubules 4 isoform X1

      See identical proteins and their annotated locations for XP_006527365.1

      UniProtKB/Swiss-Prot
      Q148A4, Q91XJ2
      UniProtKB/TrEMBL
      A0A0R4J0F3
      Conserved Domains (1) summary
      pfam15691
      Location:2 → 418
      PPP1R32; Protein phosphatase 1 regulatory subunit 32
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q148A4.1 GenPept UniProtKB/Swiss-Prot:Q148A4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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