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    Ecpas Ecm29 proteasome adaptor and scaffold [ Mus musculus (house mouse) ]

    Gene ID: 230249, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ecpasprovided by MGI
    Official Full Name
    Ecm29 proteasome adaptor and scaffoldprovided by MGI
    Primary source
    MGI:MGI:2140220
    See related
    Ensembl:ENSMUSG00000050812 AllianceGenome:MGI:2140220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0368
    Summary
    Predicted to enable molecular adaptor activity and proteasome binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in several cellular components, including centrosome; cytoplasmic vesicle; and nucleoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; cerebral cortex; cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cortical plate. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.2), bladder adult (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ecpas in Genome Data Viewer
    Location:
    4 B3; 4 32.35 cM
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58797234..58917748, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58797234..58917748, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12579 Neighboring gene STARR-seq mESC enhancer starr_10362 Neighboring gene STARR-seq mESC enhancer starr_10364 Neighboring gene STARR-seq mESC enhancer starr_10365 Neighboring gene olfactory receptor family 2 subfamily K member 2 Neighboring gene STARR-positive B cell enhancer ABC_E6181 Neighboring gene zinc finger with KRAB and SCAN domains 16 Neighboring gene prostaglandin reductase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for Murine Spermatogenesis. Sato B, et al. Biomolecules, 2023 Mar 24. PMID 37189334, Free PMC Article
    2. Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. Gorbea C, et al. J Biol Chem, 2004 Dec 24. PMID 15496406
    3. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. Lee M, et al. J Cell Biol, 2020 Feb 3. PMID 31910261, Free PMC Article
    4. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.
      Title: Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0368

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome adapter and scaffold protein ECM29
    Names
    ecm29
    proteasome-associated protein ECM29 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355696.1 → NP_001342625.1  proteasome adapter and scaffold protein ECM29 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK030369, AK043020, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
      UniProtKB/TrEMBL
      A2ALV7
      Conserved Domains (2) summary
      sd00044
      Location:1085 → 1108
      HEAT; HEAT repeat [structural motif]
      pfam13001
      Location:16 → 523
      Ecm29; Proteasome stabilizer

    2. NM_001355697.1 → NP_001342626.1  proteasome adapter and scaffold protein ECM29 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK030369, AK043020, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
      UniProtKB/Swiss-Prot
      A2ALW0, Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6
      UniProtKB/TrEMBL
      A2ALV7
      Related
      ENSMUSP00000117585.2, ENSMUST00000149301.8
      Conserved Domains (2) summary
      sd00044
      Location:1079 → 1102
      HEAT; HEAT repeat [structural motif]
      pfam13001
      Location:10 → 517
      Ecm29; Proteasome stabilizer

    3. NM_172381.3 → NP_759013.2  proteasome adapter and scaffold protein ECM29 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK030369, AK041579, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
      Consensus CDS
      CCDS18214.1
      UniProtKB/TrEMBL
      A2ALV7
      Related
      ENSMUSP00000099953.4, ENSMUST00000102889.10
      Conserved Domains (2) summary
      pfam13001
      Location:10 → 517
      Ecm29; Proteasome stabilizer
      sd00044
      Location:1079 → 1102
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      58797234..58917748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537848.4 → XP_006537911.1  proteasome adapter and scaffold protein ECM29 isoform X1

      UniProtKB/Swiss-Prot
      A2ALW0, Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6
      UniProtKB/TrEMBL
      A2ALV7
      Conserved Domains (2) summary
      sd00044
      Location:1079 → 1102
      HEAT; HEAT repeat [structural motif]
      pfam13001
      Location:10 → 517
      Ecm29; Proteasome stabilizer

    2. XM_006537850.5 → XP_006537913.1  proteasome adapter and scaffold protein ECM29 isoform X2

      UniProtKB/TrEMBL
      A2ALV7
      Conserved Domains (2) summary
      sd00044
      Location:1027 → 1050
      HEAT; HEAT repeat [structural motif]
      pfam13001
      Location:1 → 465
      Ecm29; Proteasome stabilizer
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDI5.4 GenPept UniProtKB/Swiss-Prot:Q6PDI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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