Rcvrn recoverin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcvrnprovided by MGI
Official Full Name: recoverinprovided by MGI
Primary source: MGI:MGI:97883
See related: Ensembl:ENSMUSG00000020907 AllianceGenome:MGI:97883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAR; S-modulin
Summary: Enables calcium ion binding activity. Acts upstream of or within phototransduction; regulation of calcium ion transport; and visual perception. Predicted to be located in dendrite. Is expressed in eye; photoreceptor layer; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human RCVRN (recoverin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 41.13 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (67586152..67594181)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (67695326..67703355)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

model supports the hypothesis that recoverin-specific T cell responses are major drivers of autoimmune retinopathy pathogenesis and that IL-10 is an important factor in protection
Title: Immune Cell Infiltration into the Eye Is Controlled by IL-10 in Recoverin-Induced Autoimmune Retinopathy.
Recoverin is required for rod photoreceptor light adaptation.
Title: Role of recoverin in rod photoreceptor light adaptation.
Rods and cones share the same isoforms of recoverin and GRK1, and photoactivation also triggers a calcium decline in cones
Title: Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.
recoverin may modulate the decay of light-activated PDE*, which may be responsible for the quickening of response recovery in background light.
Title: Modulation of mouse rod response decay by rhodopsin kinase and recoverin.
High anti-recoverin antibody levels were achieved in two mouse models, accompanied by significantly reduced scotopic and photopic responses on the electroretinograms.
Title: Two mouse models for recoverin-associated autoimmune retinopathy.
This is the first demonstration in an intact rod that light accelerates Rh* inactivation and that the Ca(2+)-binding protein recoverin may be required for the light-dependent modulation of Rh* lifetime.
Title: Background light produces a recoverin-dependent modulation of activated-rhodopsin lifetime in mouse rods.
recoverin undergoes light-dependent intracellular translocation in mouse rod photoreceptors
Title: Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487456

X66196 (e-PCR)
- UniSTS:160111

RCV1 (e-PCR)
- UniSTS:266689

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: recoverin

Names: 23 kDa photoreceptor cell-specific protein; cancer-associated retinopathy protein; guanylate cyclase activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009038.2 → NP_033064.1 recoverin

See identical proteins and their annotated locations for NP_033064.1

Status: VALIDATED

Source sequence(s)

CK617354, CK617615, CK627353, X66196

Consensus CDS

CCDS24859.1

UniProtKB/Swiss-Prot

P34057

UniProtKB/TrEMBL

Q2TB46

Related

ENSMUSP00000021290.2, ENSMUST00000021290.2

Conserved Domains (3) summary

COG5126
Location:14 → 182

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:65 → 127

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:37 → 90

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...